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The New Anticipatory Governance Culture for Innovation: Regulatory Foresight, Regulatory Experimentation and Regulatory Learning
(2024)With the rapid pace of technological innovation, traditional methods of policy formation and legislating are becoming conspicuously anachronistic. The need for regulatory choices to be made to counter the deadening effect ... -
LIFE CYCLE ASSESSMENT (LCA) OF A NEWLY DESIGNED METAL ADDITIVE MANUFACTURING PROCESS: MAPS (METAL ADDITIVE MANUFACTURING USING POWDER SHEETS)
(2024)Additive manufacturing (AM), a transformative technology in modern manufacturing, offers design freedom and reduced material waste. However, understanding the environmental impacts of AM processes is imperative for sustainable ... -
Hemicellulose pyrolysis: mechanism and kinetics of functionalized xylopyranose
(2024)This work analyzes the thermochemical kinetic influence of the most prominent functionalizations of the β-d-xylopyranose motif, specifically 4-methoxy, 5-carboxyl, and 2-O-acetyl, regarding the pyrolytic depolymerization ... -
Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.
(2022)Many bacterial pathogens antagonize host defense responses by translocating effector proteins into cells. It remains an open question how those pathogens not encoding effectors counteract anti-bacterial immunity. Here, we ... -
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation
(2021)The formation of Ca2+ microdomains during T cell activation is initiated by the production of nicotinic acid adenine dinucleotide phosphate (NAADP) from its reduced form NAADPH. The reverse reaction—NAADP to NAADPH—is ...