De-novo designed ??-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P
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2022Access:
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McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed ??-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, 128545, 2022Abstract:
An investigation into the effect of modified β-lysines on the growth rates of eubacterial cells is reported. It is shown that the effects observed are due to the post translational modification of Elongation Factor P (EFP) with these compounds catalysed by PoxA. PoxA was found to be remarkably promiscuous, which allowed the activity of a wide range of exogenous β-lysines to be examined. Two chain-elongated β-lysine derivatives which differ in aminoalkyl chain length by only 2 carbon units exhibited opposing biological activities – one promoting growth and the other retarding it. Both compounds were shown to operate through modification of EFP.
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http://people.tcd.ie/connonshttp://people.tcd.ie/southerj
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PUBLISHED10.1016/j.bmcl.2022.128545
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Bioorganic and Medicinal Chemistry Letters59
128545
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Immunology, Inflammation & InfectionDOI:
https://doi.org/10.1016/j.bmcl.2022.128545Metadata
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