Collagen/pristine graphene as an electroconductive interface material for neuronal medical device applications
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2022Access:
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Maughan, J. and Gouveia, P.J. and Gonzalez, J.G. and Leahy, L.M. and Woods, I. and O'Connor, C. and McGuire, T. and Garcia, J.R. and O??? Shea, D.G. and McComish, S.F. and Kennedy, O.D. and Caldwell, M.A. and Dervan, A. and Coleman, J.N. and O'Brien, F.J., Collagen/pristine graphene as an electroconductive interface material for neuronal medical device applications, Applied Materials Today, 29, 101629, 2022Download Item:
Abstract:
The growing clinical demand for electrical stimulation-based therapies requires the development of novel
conductive biomaterials that balance conductivity, biocompatibility, and mechanical performance. Traditional
conductive materials often induce scarring, due to their stiffness and poor biocompatibility, presenting chal-
lenges to their clinical translation. To address these issues, we report the development of an electroconductive
pristine graphene-based (pG) composite material for central nervous system applications, consisting of type I
collagen loaded with 60 wt% pG to yield conductivities (~1.5 S/m) necessary for efficient electrical stimulation.
Neurons and glial cells grown on composite films exhibited robust growth, and glial cells exhibited no change in
inflammatory markers. Electrical stimulation of primary neurons on the composite enhanced neurite outgrowth,
cellular viability and morphology compared to collagen controls. Finally, we demonstrated the versatility and
potential applications of the composite material for neuronal medical device applications by fabricating a range
of conductive, neural-interfacing structures, including porous scaffolds, microneedle arrays, and 3D-printed
circuits for bioelectronics. These results show that CpG composites form a versatile neurotrophic platform that
balances biocompatibility and physiologically relevant conductivity with robust mechanical properties that
allow for the production of a range of next-generation neuroprosthetic devices.
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http://people.tcd.ie/colemajhttp://people.tcd.ie/caldwelm
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Author: Coleman, Jonathan; Caldwell, Maeve
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Applied Materials Today29
101629
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Full text availableKeywords:
neuroprosthetic devices., electrical stimulation-based therapies, Neurons and glial cells, Nanomaterials, Tissue engineering, Electrical stimulation, Graphene, Collagen, Neural interface, NeuronsDOI:
http://dx.doi.org/10.1016/j.apmt.2022.101629Metadata
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