RSS 1.0Chemistry (Theses and Dissertations)
Recent Submissions
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Thiol-Ene Mediated Strategies for Peptide Cyclisation and Bioconjugation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)This thesis presents innovative methodologies for peptide cyclisation, functionalisation, and bioconjugation, providing advanced tools for biomedical research and drug discovery. Central to this work is the application of ... -
Metal@carbon nitrogenated porous architectures as novel sustainable catalysts for electrocatalytic hydrogenation of biomass-derived organics
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)The valorisation of biomass and waste feedstocks is a crucial strategy for reducing carbon emissions. Biomass stands out among renewables for its potential beyond energy production, serving as a sustainable source for ... -
Design, Synthesis, and Photophysical and Biological Studies of Naphthalimide Bioconjugates for Medicinal and Materials Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, School of Chemistry, 2025)This thesis presents significant advancements in the synthesis, characterization, and use of Naphthalimide (Nap) based biological relevant compounds for bioimaging and therapeutic applications. Extensive photophysical ... -
The development of novel synthetic methodologies for the preparation of glycosidase inhibitors
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)Sugars with heteroatoms other than oxygen in the ring (e.g. iminosugars, thiosugars) are known to exhibit interesting biological activities and possess considerable therapeutic potential. Their biological activity can be ... -
Novel Approaches to Targeted Drug Delivery via Endogenous Enzyme Activation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Current treatments used in cancer chemotherapy are limited due to their narrow therapeutic window, dose-limiting toxicity and low cancer-cell specificity, making the development of targeted drug delivery strategies an ... -
Synthesis and functionalisation of nanomaterials for biomedical diagnostic applications
(Trinity College (Dublin, Ireland). School of Chemistry, 2014)This thesis explores synthesis and functionalisation of a variety of nanomaterials for the purpose of biological detection with a potential focus on medical diagnostics. Early diagnosis is the key to disease prevention, ... -
Peptidic Activity Based Probes to Understand the Deubiquitination Machinery
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Ubiquitination is a highly conserved post-translational modification (PTM) that governs numerous critical cellular events such as protein degradation and membrane import/export. Such process is tightly regulated by a complex ... -
Novel Technique for Developing E-Textiles: Printing MXene Supercapacitors on Fabrics for Wearable Electronics
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)The increasing demand for miniaturised and flexible wearable electronics is driving the rapid growth of electronic textiles (e-textiles). In this context, microsupercapacitors (MSCs) are becoming essential as energy storage ... -
The Covalent Capture of [2]Catenanes Using Self-Templating Allyl Amide-Appended 2,6-bis(triazol-4-yl)pyridines
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)This thesis, entitled "The Covalent Capture of [2]Catenanes Using Self-Templating Allyl Amide-Appended 2,6-bis(triazol-4-yl)pyridines" describes the synthesis of self-templating [2]catenanes using the N-allyl-4-methylene ... -
Synthesis and Testing of Lipopeptide and Peptide Probes for Bacterial Lipoprotein Processing Enzymes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Bacterial lipoproteins perform essential functions in bacteria and are often crucial for survival, growth and virulence. Bacterial lipoproteins feature a fully conserved N-terminal cysteine bearing a 1,2-diacylglyceryl ... -
Rational catalyst design for photo- and electrochemical hydrogenation reactions
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Environmental pollution is an urgent threat to human health and the survival of life forms on land and in water. This crisis is fuelled by industrial, agricultural, and biomedical chemical waste, alongside the use of ... -
The Fabrication of Highly Conducting and Thermo-mechanically Robust Metal Thin Film
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Recent research from high-resolution surface probe microscopy and atomic simulation have identified that grain boundaries in [111] F.C.C. thin copper films can restructure in a region immediately below the surface. DFT ... -
Thioacid Mediated Methods for Peptide Ligation and Cyclisation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)In recent years, peptide-based therapeutics have become the focus of intensive research due to their favourable chemical properties. Consequently, the ability to efficiently synthesise a wide range of structurally diverse ... -
Electrical and structural characterisation of Transition Metal Dichalcogenides
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)This thesis explores modification of transition metal dichalcogenides (TMDs) through doping and synthesis techniques to tailor their electronic properties, including sensor technology. The work is divided into three main ... -
Investigation of Copper/Graphene Composite Materials for Enhanced Electrical Conductivity Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Copper plays a vital and ever-growing role in electrical power and signal transmission in the world today. This is due to its remarkable electrical properties, coupled with its low cost and abundance. In order to satisfy ... -
Structuring and functionalisation of chemical vapour deposited graphene
(Trinity College (Dublin, Ireland). School of Chemistry, 2016)Graphene has fascinated researchers since its discovery in 2004 due to its extraordinary physical, electrical and optical properties. In order to exploit its potential for industrial applications, the mass production of ... -
Novel hetero-fluoranthenes towards nitroaromatic sensing
(Trinity College (Dublin, Ireland). School of Chemistry, 2016)Summary: Chapter 1: This chapter gives a broad literature review to explosives and nitroaromatic sensing of polyaromatic hydrocarbons (PAHs) particularly fluoranthenes which are discussed in subsequent chapters. The concept ... -
Development of glycosylated molecular scaffolds as potential anti-cancer therapeutics
(Trinity College (Dublin, Ireland). School of Chemistry, 2016)The requirement for cell-type specific targeting of anti-cancer therapeutics is crucial to improve treatment and the pallitive care of patients. In this regard, the field of glycotherapeutics has witnessed a surge in ... -
The liquid phase exfoliation of transition metal oxides for high energy metal oxides for high energy Li-ion batteries
(Trinity College (Dublin, Ireland). School of Chemistry, 2017)Compared to other electrochemical energy sources, lithium ion (Li-ion) batteries represent the choice energy storage device for small hand held electronics such as power tools or cellphones. This is due mainly to the balance ...
