Chemistry (Scholarly Publications): Recent submissions
Now showing items 201-220 of 931
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Synthesis and Spectral Properties of gem-Dimethyl Chlorin Photosensitizers
(2020)Chlorins that bear a gem‐dimethyl group, which facilitates their resistance to oxidation, are of interest for applications in photomedicine. Herein, we present the synthesis and the photophysical properties of two ... -
Dual-binding conjugates of diaromatic guanidines and porphyrins for recognition of G-quadruplexes
(2020)The first conceptualised class of dual-binding guanine quadruplex binders has been designed, synthesised and biophysically studied. These compounds combine diaromatic guanidinium systems and neutral tetra-phenylporphyrins ... -
Graphene Oxide Functionalized with Cationic Porphyrins as Materials for the Photodegradation of Rhodamine B
(2020)Two noncovalent nanohybrids between cationic porphyrin (free-base TMPyP and zinc(II) ZnTMPyP) bearing cationic (N-methylpyridyl) groups and graphene oxide (GO) were constructed with the aim of generating a photocatalyst ... -
Synthesis, characterization, and crystal structure analysis of Zn(II) and Cd(II) coordination compounds containing 4-((pyridin-4-ylmethylene)amino)phenol Schiff-base ligand
(2020)Zn(II) and Cd(II) coordination compounds containing 4-((pyridin-4-ylmethylene)amino)phenol ligands were synthesized and then characterized using spectroscopic techniques and single crystal X-ray crystallography. The molecular ... -
Weak Interactions and Conformational Changes in Core-Protonated A 2- and A x-Type Porphyrin Dications
(2020)Individual chemical motifs are known to introduce structural distortions to the porphyrin macrocycle, be it in the core or at the periphery of the macrocycle. The interplay when introducing two or more of these known ... -
Porphyrins as Colorimetric and Photometric Biosensors in Modern Bioanalytical Systems
(2020)From the simple colorimetric detection of physiological pH range to complex DNA strand analysis ‐ the versatility of the macrocyclic system and a plenitude of chemical modifications have allowed the production of a plethora ... -
The Red Color of Life Transformed – Synthetic Advances and Emerging Applications of Protoporphyrin IX in Chemical Biology
(2020)Protoporphyrin IX (PPIX) is the porphyrin scaffold of heme b, a ubiquitous prosthetic group of proteins responsible for oxygen binding (hemoglobin, myoglobin), electron transfer (cytochrome c) and catalysis (cytochrome ... -
Targeted Synthesis of Regioisomerically Pure Dodecasubstituted Type i Porphyrins through the Exploitation of Peri-interactions
(2020)A targeted synthesis of dodecasubstituted type I porphyrins that utilizes the reaction of unsymmetrical 3,4-difunctionalized pyrroles and sterically demanding aldehydes was developed. This way, type I porphyrins could be ... -
Short-Chained Anthracene Strapped Porphyrins and their Endoperoxides
(2020)The syntheses of short‐chained anthracene‐strapped porphyrins and their Zn(II)complexes are reported. The key synthetic step is a [2+2] condensation between a dipyrromethane and an anthracene bisaldehyde, 2,2'‐((anthrace ... -
Towards triptycene functionalization and triptycene-linked porphyrin arrays
(2020)Herein, 9,10-diethynyltriptycene is investigated for its use as a rigid isolating unit in the synthesis of multichromophoric arrays. Sonogashira cross-coupling conditions are utilized to attach various porphyrins and boron ... -
Exploring the relationship between structure and activity in BODIPYs designed for antimicrobial phototherapy
(2020)A synthetic strategy to BODIPY dyes is presented giving access to a range of new compounds relevant in the context of antimicrobial photodynamic therapy (aPDT). BODIPYs with the 8-(4-fluoro-3-nitrophenyl) and the ... -
Influence of meso-linker attachment on the formation of core···π interactions in urea-functionalized porphyrins
(2020)The ability to cover the face of a porphyrin macrocycle selectively is an attractive feature for concepts such as catalysis and anion binding that are reliant on porphyrin core interactions. Herein, we have synthesized ... -
Synthetic Advances in the C-H Activation of Rigid Scaffold Molecules
(2020)The remarkable structural and electronic properties of rigid non-conjugated hydrocarbons afford attractive opportunities to design molecular building blocks for both medicinal and material applications. The bridgehead ... -
Organische Chemie
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Targeting receptor tyrosine kinase VEGFR-2 in hepatocellular cancer: Rational design, synthesis and biological evaluation of 1,2-disubstituted benzimidazoles
(2020)In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect ... -
Crystal structures of 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin as the chloroform monosolvate and tetrahydrofuran monosolvate
(2020)The crystal structures of the title compounds, two solvates (CHCl3 and THF) of a symmetric and highly substituted porphyrin, C44H2Br8F20N4 or OBrTPFPP, are described. These structures each feature a non-planar porphyrin ... -
Ethynylphenyl-Derivatized Free Base Porphyrins: Anodic Oxidation Processes and Covalent Grafting onto Glassy Carbon Electrodes
(2020)In six of seven cases, direct anodic oxidation of the ethynyl group of an ethynylphenyl-derivatized free-base porphyrin gave modified glassy carbon electrodes in which the porphyrin was strongly surface-bound, most likely ... -
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment
(2020)Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination ... -
Nucleophilic Aromatic Substitution (SNAr) and Related Reactions of Porphyrinoids: Mechanistic and Regiochemical Aspects
(2020)The nucleophilic substitution of aromatic moieties (SNAr) has been known for over 150 years and found wide use for the functionalization of (hetero)aromatic systems. Currently, several “types” of SNAr reactions have been ... -
Synthesis, crystal structure, and ADME prediction studies of novel imidazopyrimidines as antibacterial and cytotoxic agents
(Wiley, 2020)In the present study, a novel series of polyfunctionalized imidazopyrimidines 6a–u and 9a–d were efficiently constructed by a domino reaction between 2‐imino‐6‐substituted‐2,3‐dihydropyrimidin‐4(1H)‐ones 4a–d or 8a–c and ...
