Browsing Dental Science (Scholarly Publications) by Author "Moran, Gary"
Now showing items 1-13 of 13
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AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
Sullivan, Derek; Coleman, David; Moran, Gary (2005)Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. ... -
Base-metal dental casting alloy biocompatibility assessment using a human-derived 3D oral mucosal model
Fleming, Garry; Moran, Gary (2012)Nickel-chromium (Ni-Cr) alloys used in fixed prosthodontics have been associated with type IV nickel-induced hypersensitivity. We hypothesized the full-thickness human-derived oral mucosa model employed for biocompatibility ... -
The Candida albicans-Specific Gene EED1 Encodes a Key Regulator of Hyphal Extension
Sullivan, Derek; Moran, Gary (2011)The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. ... -
COMPARATIVE TRANSCRIPT PROFILING OF Candida albicans AND Candida dubliniensis IDENTIFIES SFL2, A C. albicans GENE REQUIRED FOR VIRULENCE IN A RECONSTITUTED EPITHELIAL INFECTION MODEL
Sullivan, Derek; Coleman, David; Moran, Gary (2010)Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. ... -
Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in ¿-, ß- and ¿- TLO gene function.
Sullivan, Derek; Moran, Gary (2023)The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in C. albicans we deleted all fourteen TLO ... -
A dentifrice containing salivary enzymes and xylitol exhibits superior antimicrobial activity in vitro against adherent Streptococcus mutans compared to a chlorhexidine dentifrice.
Moran, Gary (2023)Human saliva contains natural antimicrobial enzymes. In this in-vitro study, we evaluate the antimicrobial activity of a dentifrice containing a salivary enzyme complex (SEC) with xylitol versus a standard 0.12% chlorhexidine ... -
Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression
Sullivan, Derek; Moran, Gary (2010)Candida dubliniensis is closely related to C. albicans, however it is responsible for fewer infections in humans and is less virulent in animal models of infection. C. dubliniensis forms fewer hyphae in vivo and this may ... -
DIFFERENTIAL VIRULENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS: A ROLE FOR TOR KINASE?
Sullivan, Derek; Moran, Gary (2011)Candida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C. albicans is the most prevalent species in the human gastrointestinal tract and is responsible for far more opportunistic ... -
Does fluoride exposure impact on the human microbiome?
Moran, Gary; Zgaga, Lina; Daly, Blanaid (2023)Fluoride is added to drinking water in some countries to prevent tooth decay (caries). There is no conclusive evidence that community water fluoridation (CWF) at WHO recommended concentrations for caries prevention has any ... -
Expansion of the TLO gene family enhances the virulence of Candida species
Sullivan, Derek; Moran, Gary; Flanagan, Peter (2018) -
Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
Enjalbert, Brice; Moran, Gary; Vaughan, Claire; Yeomans, Tim; MacCallum, Donna; Quinn, Janet; Coleman, David; Brown, Alistair; SULLIVAN, DEREK (Wiley-Blackwell, 2009)Candida albicans is more pathogenic than Candida dubliniensis. However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two ... -
Purification and germination of Candida albicans and Candida dubliniensis chlamydospores cultured in liquid media
Citiulo, Francesco; Moran, Gary; COLEMAN, DAVID; SULLIVAN, DEREK (2009-06-30)Candida albicans and Candida dubliniensis are the only Candida species that have been observed to produce chlamydospores. The function of these large, thick-walled cells is currently unknown. In this report we describe ... -
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents.
Moran, Gary; Sullivan, Derek (2023)Mediator is a complex of polypeptides that plays a central role in the recruitment of RNA polymerase II to promoters and subsequent transcriptional activation in eukaryotic organisms. Studies have now shown that Mediator ...