Browsing Mechanical & Manufacturing Eng (Scholarly Publications) by Author "Hoey, David"
Now showing items 21-32 of 32
-
Melt electrowritten scaffold architectures to mimic tissue mechanics and guide neo-tissue orientation
Tornifoglio, Brooke; Kelly, Daniel; Hoey, David (2024)All human tissues present with unique mechanical properties critical to their function. This is achieved in part through the specific architecture of the extracellular matrix (ECM) fibres within each tissue. An example of ... -
A meta-analysis of the diagnostic accuracy of hounsfield units on computed topography relative to dual-energy X-ray absorptiometry for the diagnosis of osteoporosis in the spine surgery population.
Hoey, David (2021)Background: The preoperative identification of osteoporosis in the spine surgery population is of crucial importance. Limitations associated with dual-energy x-ray absorptiometry, such as access and reliability, have ... -
Perspectives on the Mechanics of Fracture and Biological Materials
Hoey, David (Lulu Publishing, 2022) -
Pressure-induced mesenchymal stem cell osteogenesis is dependent on intermediate filament remodeling.
Hoey, David (2019)Macroscale loading of bone generates a complex local mechanical microenvironment that drives osteogenesis and bone mechanoadaptation. One such mechanical stimulus generated is hydrostatic pressure (HP); however, the effect ... -
Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling.
Hoey, David (2021)The benefits of physical loading to skeletal mass are well known. The primary cilium has emerged as an important organelle in bone mechanobiology/mechanotransduction, particularly in mesenchymal stem/stromal cells, yet the ... -
A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells.
Kelly, Daniel; Hoey, David (2011)Bone turnover is a mechanically regulated process, coordinated in part by the network of mechanosensitive osteocytes residing within the tissue. The recruitment and bone forming activity of the mesenchymal derived osteoblast ... -
Sol–gel‑templated bioactive glass scaffold: a review
Hoey, David (2024)Purpose This review paper explores diverse synthesis strategies within the sol–gel technique for producing silicate bioglass with a focus on tailoring these materials for bone scaffold design. Method A comprehensive ... -
Surface Free Energy Dominates the Biological Interactions of Postprocessed Additively Manufactured Ti-6Al-4V
Colavita, Paula; Hoey, David (2022)Additive manufacturing (AM) has emerged as a disruptive technique within healthcare because of its ability to provide personalized devices; however, printed metal parts still present surface and microstructural defects, ... -
TGFß1 - induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner.
Hoey, David (2016)The recruitment of mesenchymal stem cells (MSCs) is a crucial process in the development, maintenance and repair of tissues throughout the body. Transforming growth factor-β1 (TGFβ1) is a potent chemokine essential for the ... -
TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium
Hoey, David (2018)Skeletal homeostasis requires the continued replenishment of the bone forming osteoblast from a mesenchymal stem cell (MSC) population, a process that has been shown to be mechanically regulated. However, the mechanisms ... -
Utilizing Osteocyte Derived Factors to Enhance Cell Viability and Osteogenic Matrix Deposition within IPN Hydrogels.
Hoey, David (2020)Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone ...