Browsing School of Dental Sciences by Sponsor "Health Research Board (HRB)"
Now showing items 1-20 of 21
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AIR AND SURFACE CONTAMINATION PATTERNS OF METHICILLIN-RESISTANT Staphylococcus aureus ON EIGHT ACUTE HOSPITAL WARDS
(2014)BACKGROUND. Methicillin-resistant Staphylococcus aureus (MRSA) can be recovered from hospital air and from environmental surfaces. This poses a potential risk of transmission to patients. OBJECTIVE. To investigate ... -
AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
(2005)Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. ... -
CHARACTERIZATION OF A NOVEL ARGININE CATABOLIC MOBILE ELEMENT (ACME) AND STAPHYLOCOCCAL CHROMOSOMAL CASSETTE mec COMPOSITE ISLAND WITH SIGNIFICANT HOMOLOGY TO STAPHYLOCOCCUS EPIDERMIDIS ACME TYPE II IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS GENOTYPE ST22-MRSA-IV
(2011)The arginine catabolic mobile element (ACME) is prevalent among ST8-MRSA-IVa (USA300) isolates and evidence suggests that ACME enhances the ability of ST8-MRSA-IVa to grow and survive on its host. ACME has been identified ... -
Co-carriage of diverse vancomycin-resistant Enterococcus faecium ST80-lineages by 70% of patients in an Irish hospital
(2025)Background: Vancomycin-resistant Enterococcus faecium (VREfm) are significant nosocomial pathogens. Irish VREfm comprise diverse vanA-encoding ST80-complex type (CT) lineages. Recent studies indicate that within-patient ... -
COMPARATIVE ADHERENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS TO HUMAN BUCCAL EPITHELIAL CELLS AND EXTRACELLULAR MATRIX PROTEINS
(2014)Candida albicans and Candida dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, the former is a far more successful coloniser and pathogen of humans. The purpose of the current ... -
CONTROL OF BACTERIAL CONTAMINATION OF WASHBASIN TAPS AND OUTPUT WATER USING ECASOL: A ONE YEAR STUDY
(2012)BACKGROUND: Contaminated washbasin taps and output water are an important source of bacteria that may cause nosocomial infection. A five-week pretreatment study of hot and cold water from 15 washbasin taps at Dublin ... -
DIFFERENTIAL FILAMENTATION OF CANDIDA ALBICANS AND C. DUBLINIENSIS IS GOVERNED BY NUTRIENT REGULATION OF UME6 EXPRESSION
(2010)Candida dubliniensis is closely related to Candida albicans; however, it is responsible for fewer infections in humans and is less virulent in animal models of infection. C. dubliniensis forms fewer hyphae in vivo, and ... -
Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression
(2010)Candida dubliniensis is closely related to C. albicans, however it is responsible for fewer infections in humans and is less virulent in animal models of infection. C. dubliniensis forms fewer hyphae in vivo and this may ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
(2007)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the ... -
A HOSPITAL OUTBREAK OF LINEZOLID-RESISTANT AND VANCOMYCIN-RESISTANT Enterococcus faecium HARBOURING AN optrA-ENCODING CONJUGATIVE PLASMID INVESTIGATED BY WHOLE GENOME SEQUENCING
(2020)Background: Linezolid is an antibiotic used to treat infections caused by multi-drug-resistant Gram-positive bacteria. Linezolid resistance in enterococci has been reported with increasing frequency, with a recent rise in ... -
IDENTIFICATION AND CHARACTERIZATION OF THE MULTIDRUG RESISTANCE GENE cfr IN PANTON-VALENTINE LEUKOCIDIN-POSITIVE ST8-METHICILLIN-RESISTANT Staphylococcus aureus-IVa (USA300)
(2010)The staphylococcal cfr gene mediates resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A, a phenotype that has been termed PhLOPSA. The cfr gene has mainly been associated with ... -
IMMERSION OF DEBRIDED DIABETIC FOOT ULCER (DFU) TISSUE IN ELECTROCHEMICALLY GENERATED PH NEUTRAL HYPOCHLOROUS ACID SIGNIFICANTLY REDUCES THE MICROBIAL BIOBURDEN: WHOLE-GENOME SEQUENCING OF Staphylococcus aureus, THE MOST PREVALENT SPECIES RECOVERED
(2023)Background: Diabetic foot ulcer infections (DFUIs) are the leading cause of lower limb amputations, mediated predominantly by Staphylococcus aureus. pH neutral electrochemically-generated hypochlorous acid (anolyte) is a ... -
Investigation into the Genotypes and Phenotypes of Fusobacterium nucleatum subsp. polymorphum Isolates Recovered from Oral Leukoplakia
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2024)Fusobacterium nucleatum is Gram negative anaerobe of the oral cavity, where it plays a key role as a bridging organism in the plaque biofilm between early colonisers of the tooth surface, such as streptococcal species, and ... -
A Large-Scale Investigation of the Molecular Epidemiology and Phylogenetics of Vancomycin-Resistant Enterococcus faecium from Irish Hospitals: A Microbial Genomics Approach
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2024)Enterococcus faecium is a commensal bacterium of the human gastrointestinal tract that has emerged as an important opportunistic pathogen, particularly in immunocompromised patients. Multi-drug resistant strains, notably ... -
METICILLIN-RSISTANT Staphylococcus aureus TRANSMISSION AMONG HEALTHCARE WORKERS, PATIENTS AND THE ENVIRONMENT IN A LARGE ACUTE HOSPITAL UNDER NON-OUTBREAK CONDITIONS INVESTIGATED BY WHOLE-GENOME SEQUENCING
(2021)Background: The role of meticillin-resistant Staphylococcus aureus (MRSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MRSA transmission in non-outbreak settings is poorly understood. Aims: ... -
Meticillin-susceptible Staphylococcus aureus transmission among healthcare workers, patients and the environment in a large acute hospital under non-outbreak conditions investigated using whole-genome sequencing
(2022)Background: The role of meticillin-susceptible Staphylococcus aureus (MSSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MSSA transmission events (TEs) is poorly understood. Aims: ... -
Oral Health Status of community dwelling older adults and its relationship with general health conditions
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2020)Background The ageing population is one of the great challenges that will confront health services in developed countries in the coming years. It is estimated that by 2050, the number of adults aged 60 years and older ... -
PROTRACTED TRANSMISSION AND PERSISTENCE OF ST80 VANCOMYCIN-RESISTANT Enterococcus faecium CLONAL COMPLEX TYPES CT2933, CT2932 AND CT1916 IN A LARGE IRISH HOSPITAL: A 39-MONTH WGS STUDY
(2024)Background: Vancomycin-resistant Enterococcus faecium (VREfm) are significant nosocomial pathogens. Sequence type (ST)80 vanA-encoding VREfm predominate in Irish hospitals, but their transmission is poorly understood. Aims: ...
