School of Biochemistry & Immunology: Recent submissions
Now showing items 161-180 of 1067
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Structural and Functional Studies of Lipoprotein Signal Peptidase (LspA) from Methicillin-resistant Staphylococcus aureus(MRSA)
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Antimicrobial resistance has drawn more and more attention from the world public health community and global leaders in the past decade. Staphylococcus aureus is one of the most threatening clinical pathogens and has caused ... -
Thermoregulation in the Brain and Body: Understanding the Influence of Memory on Innate Responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Thermoregulation is the ability for an organism to maintain a specific internal temperature while existing in an environment with constantly changing external temperatures. This is a critical homeostatic response and the ... -
Chitin-derived STING Activators as Adjuvants and Therapeutics
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)A significant challenge in the advancement of vaccine research is a lack of adjuvants that can safely drive potent cellular immunity against intracellular pathogens and cancer, a problem only exacerbated by our limited ... -
Prolonged oral coenzyme Q10-β-cyclodextrin supplementation increases skeletal muscle complex I+III activity in young Thoroughbreds
(2020)In summary, this study demonstrated that oral supplemen- tation of young, healthy untrained Thoroughbreds on a pasture and oat diet with a CoQ 10 -β-cyclodextrin inclusion complex via syringe significantly increased ... -
Cold acclimation and oxygen consumption in the thymus
(2006)Mitochondrial uncoupling protein 1 is usually associated with brown adipose tissue but has recently been discovered in rat and mouse thymus. We wished to establish whether there was a thermogenic role for UCP 1 in thymus ... -
Uncoupling mechanism and redox regulations of mitochondrial uncoupling protein UCP1
(2018)Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these ... -
Effect of dietary restriction and subsequent realimentation on hepatic oxidative phosphorylation in cattle
(2021)Compensatory growth (CG) is a naturally accelerated growth which occurs upon realimentation, following a prior period of dietary restriction. The process is harnessed worldwide as a management practice to reduce feed costs ... -
Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
(2020)Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils and monocytes. While the role of neutrophils ... -
Mitochondrial abundance and function in skeletal muscle and liver from Simmental beef cattle divergent for residual feed intakee
(2020)Cellular mitochondrial function has been suggested to contribute to variation in feed efficiency (FE) among animals. The objective of this study was to determine mitochondrial abundance and activities of various mitochondrial ... -
The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thoroughbred Horses
(2017)The Thoroughbred horse is a tremendous athletic breed, which can be attributed to years of genetic selection for speed and stamina. This selection has led to the Thoroughbred having a very high aerobic capacity relative ... -
Helminth products promote anti-inflammatory trained innate immunity by imprinting long-term hematopoietic stem cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Recent research has shown that immunological memory is not confined to the cells of the adaptive immune system but can be imbued upon innate immune cells, including monocytes and macrophages, in a process known as trained ... -
TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
(2021)Background Natural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. ... -
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
(2021)Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic ... -
The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3
(2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Mycobacterium tuberculosis Limits Host Glycolysis and IL-1? by Restriction of PFK-M via MicroRNA-21
(2020)Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we ... -
Technological Approaches for Improving Vaccination Compliance and Coverage
(2020)Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical ... -
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
(2020)Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non-infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination ... -
Editorial: Challenges in Vaccinology
(2020)The COVID19 pandemic has focused minds as rarely before on the vital contribution of vaccines to modern life. In addition to issues related to antigen identification, vaccine adjuvants, vectors and formulations, knowledge ... -
Prevention and treatment of COVID-19 disease by controlled modulation of innate immunity
(2020)The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global public health and economies. Human coronaviruses ...
