School of Biochemistry & Immunology: Recent submissions
Now showing items 21-40 of 1067
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Innate immune regulation of secretory IgA responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Owing to its unique biological function, the gastrointestinal tract (GIT) is constitutively exposed to a plethora of antigens including those of dietary and environmental origin. In addition, the enormous bacterial burden ... -
Innate DNA sensing mechanisms and PYHIN protein function in epithelial cell lines
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)In the last decade mechanisms for innate immune sensing of pathogens and self nucleic acids have been defined. For cytosolic sensing of DNA, the adaptor protein STING has a central role, operating downstream of DNA sensors ... -
Amino acid-dependant mTORC1 and cMyc signaling is essential for Natural Killer cell metabolic and functional responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)Natural killer [NK) cells are innate cytotoxic lymphocytes that are essential to the immune response against virally infected and transformed cells. NK cells directly kill target cells through the release cytotoxic granules. ... -
Investigation of immuno-regulatory mechanisms during Staphylococcus aureus colonisation and infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)1.1 Staphylococcus aureus infections and treatment options Staphylococcus aureus: (S. aureus) is a Gram-positive coccal bacterium. It is a facultative anaerobe which can be distinguished from other such staphylococci due ... -
Identification of novel immunomodulators in the Vaccinia virus genome
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)A crucial early step for the initiation of an effective anti-viral response after sensing the presence of viruses is the activation of the transcription factors nuclear factor kappa-B (NFkB) and interferon regulatory factors ... -
Defining functional interactions between human B cells and invariant natural killer T cells form health donors and patients wiht chronic lymphocytic leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Invariant natural killer T (iNKT) cells are a minor population of innate T cells that express semi-invariant T cell receptors that recognise glycolipid antigens (Ag) presented by CD1d. Upon activation, iNKT cells kill ... -
The role of phagocytosis and circadian entrainment in regulating innate immunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)Lifestyles in wide parts of the world have changed. Exposure to artificial light at night, intermittent meals, night-/ shift-work is part of the everyday life for many people, leading to chronic disruption of their internal ... -
Investigating the role of inflammatory caspases in colorectal cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. The activation mechanisms and downstream signalling pathways ... -
Examination of the queuine-insertase RNA modificaton in breast cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Queuine is a bacterial-derived metabolite that is harvested by eukaryotes and incorporated into tRNA at GUN anticodon sequences (N=A/C/G/U) by displacing the nuclear encoded guanine base by the queuine-insertase enzyme. ... -
Induction of anti-tumour immune responses by overcoming tumour immune subversion
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Immunotherapy has considerable potential to improve disease outcome and survival of patients with cancer. Tumour eradication by the immune system is largely dependent on pro-inflammatory signals and effector cell infiltration ... -
Expression and functional analysis of nucleic acid sensors in the CNS : implications for infection, sterile brain injury and neurodegeneration
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)The recognition of nucleic acids is essential in combating viral and bacterial pathogens. The sensors and pathways involved in RNA/DNA detection have only recently been discovered and have expanded over the last number of ... -
Investigation into the role of MNDA in the type 1 1FN response in human monocytes
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Type I interferons (IFNs) are secreted by cells in response to pattern recognition receptor (PRR) stimulation by viral nucleic acids and have a broad range of antiviral effects. The human PYHIN proteins, namely AIM2, IFI16, ... -
Cold sensitive engrams control whole-body thermoregulatory responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Environmental thermal challenges trigger the brain to coordinate both autonomic and behavioral responses to maintain optimal body temperature. It is unknown how temperature information is precisely stored and retrieved in ... -
The Effects of Neuroinflammation and Alzheimer's-like pathology on Gamma Frequency Oscillations in Mice
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, Biochemistry & Immunology, 2024)Gamma frequency (20-80 Hz) oscillations are rhythmic neuronal network activities which are required in many cognitive processes, including working memory and selective attention. Neuroinflammation is increasingly seen ... -
Investigating the diversity and therapeutic potential of circulating and tissue-resident memory CD4+ T cells elicited in response to Staphylococcus aureus
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Staphylococcus aureus is one of the most important pathogens globally to which a vaccine would prove enormously valuable. Furthermore, S. aureus can colonize humans asymptomatically. Resultingly, S. aureus elicits pre-existing ... -
Exploring the Mitochondrial Metabolite Itaconate and Mitochondrial Glutathione in Inflammation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Immunometabolism is a new branch of immunology that studies the interplay between metabolism and immune cell activation. Mitochondria play a pivotal role in immunometabolism as they host key metabolic processes such as ... -
Insights into how mitochondria regulate the neurodegenerative process
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)Nerve terminal dysfunction is thought to be an early event in neurodegeneration that precedes neuronal death in the brain. Mitochondria are implicated as instigators of nerve terminal dysfunction and subsequent synaptic ... -
Structural and Functional Studies of the Thromboxane A2 Receptor for Rational Drug Design
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)The thromboxane A2 receptor (TP) is a G protein-coupled receptor (GPCR) that belongs to the prostanoid subfamily of class A GPCRs. TP plays critical roles in cardiovascular function as it leads to platelet aggregation ... -
The Role of Interleukin-18 in Barrett's Disease and progression to Oesophageal Adenocarcinoma.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Oesophageal adenocarcinoma (OAC) is characterised as a dismal cancer, with a 5-year survival rate in western countries of less than 20%. The disease is an inflammation-associated cancer, which can begin as a pre-neoplastic ... -
p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Sestrins (SESN1-3) are evolutionarily conserved, stress-responsive proteins known for their significant roles in regulating cellular stress, homeostasis, and metabolism. Initially identified as a target of p53, a critical ...
