School of Biochemistry & Immunology: Recent submissions
Now showing items 81-100 of 1067
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IL-17 and IL-17-producing cells in protection versus pathology
(2023)IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced ... -
PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
(2023)PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. We characterize mouse PYHIN IFI207, which we find is not involved ... -
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing
(2022)Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however, the role of circadian rhythms ... -
The antiviral potential of itaconate and its derivative 4-Octyl itaconate against RNA viruses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Itaconate is a Krebs cycle derived metabolite which has been shown to have anti-inflammatory properties. This specially applies to derivatives of itaconate, notably the cell permeable analogue 4-octyl itaconate (4-OI) which ... -
Investigating the Signalling and Function of C5aR2
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Complement component 5a receptor 2 (C5aR2) is an enigmatic receptor for anaphylatoxin C5a. It was initially thought to be a decoy receptor, competitively binding to C5a to negatively regulate C5aR1 signalling. However, ... -
Understanding the mechanism and functional effects of caspase-11 regulated nitric oxide production during inflammation and cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Inflammatory caspases are a group of cysteine aspartic proteinases essential for the inflammatory process, but when dysregulated are implicated in inflammatory diseases and cancer-associated chronic inflammatory events. ... -
Particulate adjuvants for use in cancer vaccination
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)It is estimated that 1 in 2 people will develop cancer in their lifetime, highlighting the urgent need for improved preventative and therapeutic strategies. Cancer immunotherapy has emerged as a key pillar of cancer ... -
Investigating the Role of TLR8 in Inflammatory and Antiviral Responses in Human Polymorphonuclear Leukocytes (PMNs)
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023) -
Characterization of Staphylococcal protein A cellular interactions to facilitate its development as a vaccine antigen
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The development of a vaccine from bench to bedside is a lengthy and complex process, which is so rarely fully realized and followed throughout. During the course of this project, we have been able to follow the development ... -
Innate immune activity in endometrial epithelial cells: implication for female fertility
The maternal local immune system is key to a successful pregnancy. Maternal immunity is required to initiate pregnancy related processes, whilst controlling and being active against any infections or malignancies that may ... -
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
(Springer Nature, 2023-03-08)Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory ... -
Mechanisms of gasdermin pore formation in response to viral sensing in human respiratory epithelial cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)A key component of the innate immune response to infection or cellular stress is the activation of inflammasomes which leads to gasdermin (GSDM) pore formation, interleukin-1β (IL-1β) release and lytic cell death. GSDMs ... -
Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ... -
Innate immune potential of bovine respiratory epithelial cells: role in viral infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory epithelial cells have important defence activities against respiratory viruses. While their physical barrier function is well described, the molecular mechanisms responsible for how epithelial cells initiate, ... -
NLRP1 drives inflammasome responses in the human respiratory epithelium
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The airway epithelium is now considered crucial to the orchestration of respiratory inflammatory responses and tissue remodelling. It functions as the first line of defence against inhaled concomitants and coordinates the ... -
Long term detection and quantification of SARS-CoV-2 RNA in wastewater in Bahrain
(2022)Wastewater-based epidemiology is a corroborated environmental surveillance tool in the global fight against SARS-CoV-2. The analysis of wastewater for detection of SARS-CoV-2 RNA may assist policymakers to survey a specific ... -
In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis.
(2022)Human milk oligosaccharides (HMOs) form the third most abundant component of human milk and are known to convey several benefits to the neonate, including protection from viral and bacterial pathogens, training of the ... -
Adrenergic, Circadian, and Dietary Regulation of Interleukin-17A Expression by Adipose Gamma-Delta T Cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Adipose tissue is home to a unique population of IL-17A expressing Gamma-Delta T cells (Gamma-Delta17 T cells), which are necessary for maintaining body temperature during cold environmental temperatures. However, the ... -
Pre-clinical development of NOX2/ROS blood-based biomarker of TBI
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)There is an urgent need to develop predictive biomarkers for traumatic brain injury (TBI) to aid clinical diagnosis and treatment of head injury patients. NADPH oxidase 2 (NOX2) activity and oxidized biomarkers are being ... -
Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ...
