Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Subject "Ph.D. Trinity College Dublin"
Now showing items 41-60 of 88
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Investigation of the PSD-95 / nNOS protein interaction as a target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Previous studies have demonstrated that nitric oxide (NO) synthase inhibitors are as efficacious as tricyclic antidepressants in preclinical antidepressant screening procedures and in attenuating behavioural deficits ... -
Investigation of the solid-state, powder flow and tabletability properties of comminuted active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)An understanding of the effect of processing on the solid-state properties of active pharmaceutical ingredients (APIs) is essential for product manufacturing success. During product development it is possible to induce ... -
Investigations into the anti allergy properties of novel benzocycloalkanone based compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)An allergic response occurs because of a hypersensitive response by mast cells to an otherwise innocuous environmental substance. Allergen challenge causes mast cell degranulation, resulting in the release of mast cell ... -
Investigations of a spray-drying method for producing nanoporous / nano-particulate microparticles (NPMPs) of proteins and protein-excipient composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The research, presented in this thesis, concerns the application of a spray-drying method to produce nanoporous/nano-particulate microparticles (NPMPs) of proteins, stabilising excipients and composites. The proposed method, ... -
Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The studies in this thesis explored the solid state and inhalation properties of various systems produced by the spray drying technique. The work focused on the feasibility analysis of spray drying as a means of producing ... -
Investigatons of the potential of crystalline excipients to prevent the process-induced amorphisation of active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)The focus of this thesis was to evaluate the impact of mechanical activation (milling and dry mixing) and spray drying on the crystallinity of selected active pharmaceutical ingredients (APIs) and to explore the feasibility ... -
Kinetic and structural studies of novel isosorbide-based ligand binding to esterase enzymes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The main goal of the project described herein was to examine and rationalise the binding of a novel class of compound based on isosorbide to cholinesterase enzymes. The compounds of interest had been prepared within the ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ... -
Mechanistic aspects of the degradation and drug release properties of poly-alpha-hydroxyl aliphatic ester nano- and microparticle
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Particulate systems based on the polymers of lactic and glycolic acids have been extensively investigated as drug delivery technologies, particularly as vehicles to achieve controlled release. The release kinetics from ... -
Mechanistics aspects of the release of drugs from hydrophilic polymer matrices
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)Hydrophilic polymers, which both swell and erode, are widely used to produce sustained release of drugs from monolithic matrices, and have been extensively reviewed in the literature (Alderman 1984), (Peppas and Korsmeyer ... -
Multimodal magnetic resonance imaging in animal models of depression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Depression Is a debilitating and potentially fatal disorder for which the pathophysiology underlying the illness is still unknown. Aberrant glutamatergic neurotransmission and altered astrocyte function have recently been ... -
Neuronal Nitric oxide synthase : a novel target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main ... -
Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed ... -
Optimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The use of the pulmonary route is a viable alternative administration route to injection, in particular for drugs with poor systemic bioavailability upon oral delivery such as therapeutic peptides and proteins. However, ... -
Pharmaceutical cocrystals : a contribution to fundamental studies addressing solubility, dissolution, formation and characterisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis has focused on the study of pharmaceutical cocrystals. The investigations have addressed the solubility, dissolution and stability of cocrystals as well as the evaluation of selected production techniques, in ... -
Pharmaceutical services for patients in methadone treatment in Ireland and the introduction of the Methadone Protocol Scheme
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Methadone is a long-acting opiate commonly used in substitution therapy for heroin addiction. In Ireland, prior to 1998, people requiring treatment for opiate addiction could either attend the National Drug Treatment Centre, ... -
Pharmaceutical stability and prodrug studies on the antidepressant bupropion
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)This thesis describes the work carried out at the School of Pharmacy and Pharmaceutical Sciences, Trinity College on the pharmaceutical stability and prodrug studies on the antidepressant bupropion. Chapter 1 gives an ... -
Physiochemical studies of diclofenac salts and the effect of basis excipients on their dissolution
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)This study involved investigation of the physicochemical properties of diclofenac salts prepared from a range of organic bases. The salts examined included five novel salts of diclofenac, prepared from the following bases: ... -
Platelets decrease chemotherapy -induced cancer cell damage by increasing cell survival : mechanisms and significance
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cancer cells grow without the restraints of feedback control mechanisms that regulate normal tissue or organ growth, such as apoptosis, leading to Increased cancer cell survival. Deregulation of apoptosis has been Implicated ... -
Polyamines and polyamine antagonists in cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Polyamines are ubiquitous components of all eukaryotic cells and are found in brain tissue. A number of studies have shown that changes in the levels of polyamines occur following cerebral ischaemia. However, whether ...