Browsing Administrative Staff Authors by Subject "Bioengineering"
Now showing items 1-10 of 10
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Biomaterials and scaffolds for tissue engineering
(2011)Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by ... -
Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds.
(2011)Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this in mind, we sought to determine the effects of crosslinking on both the ... -
The Development of Non-Viral Gene-Activated Matrices for Bone Regeneration Using Polyethyleneimine (PEI) and Collagen-Based Scaffolds
(2012)The healing potential of scaffolds for tissue engineering can be enhanced by combining them with genes to produce gene-activated matrices (GAMs) for tissue regeneration. We examined the potential of using polyethyleneimine ... -
Imaging Arterial Fibres Using Diffusion Tensor Imaging Feasibility Study and Preliminary Results
(2010)MR diffusion tensor imaging (DTI) was used to analyze the fibrous structure of aortic tissue. A fresh porcine aorta was imaged at 7T using a spin echo sequence with the following parameters: matrix 128 x 128 pixel; slice ... -
Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
(2010)Artificial tissue growth requires cells to proliferate and differentiate within the host scaffold. As cell function is governed by mechano-sensitive selection, tissue type is influenced by the microscopic forces exposed ... -
Mechanical characterisation of a customised decellularized scaffold for vascular tissue engineering
(Elsevier, 2012)Several challenges persist when attempting to utilise decellularized tissue as a scaffold for vascular tissue engineering. Namely: poor cell infiltration/migration, excessive culture times associated with repopulating the ... -
Mesenchymal stem cell fate is regulated by the composition and mechanical properties of Collagen Glycosaminoglycan scaffolds
(Elsevier, 2012)In stem cell biology, focus has recently turned to the influence of the intrinsic properties of the extracellular matrix (ECM), such as structural, composition and elasticity, on stem cell differentiation. Utilising ... -
A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
(2010)Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold. Yet, causal relationships linking scaffold strain magnitudes and inlet fluid velocities to specific cell ... -
Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
(2011)Although osteoporosis reduces overall bone mass causing bone fragility, recent studies report that the remaining bone tissue is significantly stiffer. Preliminary studies indicate that alterations in bone tissue mineral ... -
Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen GAG scaffold
(2010)Anchorage dependent cells respond to mechanical and physical properties of biomaterials. One such cue is a material?s mechanical stiffness. We compared the osteogenic potential of collagen glycosaminoglycan (CG) scaffolds ...