Administrative Staff Authors : Recent submissions
Now showing items 721-740 of 840
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Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease
(BMJ, 1989)T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced ... -
Neurofilament expression in human T lymphocytes
(British Society for Immunology, 1993)The expression of intermediate filaments in normal cells is mainly determined by their embryonal developmental origin. Flow cytometry using monoclonal antibody RT97 demonstrated that neurofilament was detectable in the ... -
Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line
(British Society for Immunology, 1993)Using the T-cell lymphoma line HuT 78, and a clone derived from HuT 78, designated K-4, the role of protein kinase C (PKC) isozymes in the expression of a variety of T-cell surface antigens was investigated. HuT 78 expresses ... -
Evolution of the Cerebellar Cortex: Selective expansion of prefrontal-projecting lobules
(2009)It has been suggested that interconnected brain areas evolve in tandem because evolutionary pressures act on complete functional systems rather than individual brain areas. The cerebellar cortex has reciprocal connections ... -
Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation
(BMJ, 1994)Helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in ... -
Microalbuminuria in inflammatory bowel disease
(BMJ, 1994)Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined ... -
Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78
(The American Society for Biochemistry and Molecular Biology, 1995)Tumor necrosis factor (TNF) is a pleiotropic cytokine which has both cytotoxic and proliferative effects. HuT 78, a T-cell line derived from a Sezary lymphoma, is resistant to the cytotoxic effects of TNF, suggesting that ... -
Protein kinase C isoform expression in CD45RA+ and CD45RO+ T lymphocytes
(Blackwell, 1995)Differences in levels of specific enzymes utilized in intracellular signalling could be a factor in the distinct signalling properties observed in memory and naive T cells. We have studied the expression of both classical ... -
Expression of CD44 on rheumatoid synovial fluid lymphocytes
(BMJ, 1995)OBJECTIVES--To investigate the involvement of the adhesion molecule CD44 in the homing of lymphocytes to synovial tissue, by examining the density of expression and molecular mass of CD44 on rheumatoid synovial fluid ... -
Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signalling molecules for cytoskeleton-dependent morphological changes in activated T cells
(Oxford University Press, 1995)Signaling through the leukocyte function-associated antigen 1 (LFA-1) molecule has previously been shown to induce homotypic aggregation in T cells and to induce cytoskeletal changes in T lymphoma cells. In this study we ... -
Helicobacter pylori increases proliferation of gastric epithelial cells
(BMJ, 1996)The direct and indirect effects of helicobacter pylori on cell kinetics of gastric epithelial cell line AGS were investigated by flow cytometric analysis of Ki-67 positive cells and by MTT assay. Flow cytometric analysis ... -
Microalbuminuria correlates with intestinal histopathological grading in patients with inflammatory bowel disease
(BMJ, 1996)It has previously been shown that microalbuminuria is a useful disease activity marker for inflammatory bowel disease (IBD). Microalbuminuria correlates strongly with the markers of clinical and laboratory disease activity ... -
Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation
(BMJ, 1996)BACKGROUND--Studies have suggested that expression of the adhesion molecule CD44 may be of prognostic importance in gastric cancer. In addition, there is strong evidence that Helicobacter pylori has a role in gastric cancer. ... -
Protein kinase C isotypes theta, delta and eta in human lymphocytes: differential responses to signalling through the T-cell receptor and phorbol esters
(1997)The repertoire of novel and atypical protein kinase C (PKC) isotypes present in human T cells and their subcellular localization have not been fully characterized. We detected calcium-independent PKC activity in whole cell ... -
Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells
(BMJ, 1997)BACKGROUND: Elements of the mucosal immune system may play an important part in regulating epithelial barrier function in the intestinal tract. Intraepithelial lymphocytes (IELs) represent a subtype of immunocyte which is ... -
Identification and characterization of a metalloprotease activity from Helicobacter pylori
(American Society for Microbiology, 1997)Helicobacter pylori produces a metalloprotease with a native molecular size of approximately 200 kDa, as determined by size-exclusion chromatography. Subcellular distribution studies demonstrated that the activity was ... -
Subcellular localization and translocation of protein kinase C isoforms zeta and epsilon in human peripheral blood lymphocytes
(1997)The calcium-independent members of the protein kinase C (PKC) family may play a significant role in T cell function. We have characterized the subcellular localization and redistribution of calcium-independent kinase C ... -
Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators
(American Society of Microbiology, 1998)Helicobacter pylori colonizes the gastric mucosa, and the infection is related to the development of diverse gastric pathologies, possibly by directly or indirectly affecting epithelial-cell function. We analyzed the ... -
H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control
(British Medical Association, 1998)Extracellular matrix proteins and proteins involved in epithelial adhesion are essential for maintenance of tissue structure. Helicobacter pylori is the major aetiological agent in peptic ulcer disease and has been shown ... -
Inside the crawling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes beta(I) and delta
(1998)T cells activated via integrin receptors can polarize and start crawling locomotion with repeated cycles of cytoskeletal reassembly processes, many of which depend on phosphorylation. We demonstrate that protein kinase C ...
