Browsing Administrative Staff Authors (Scholarly Publications) by Author "O'BRIEN, FERGAL"
Now showing items 1-15 of 15
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Biomaterials and scaffolds for tissue engineering
O'BRIEN, FERGAL (2011)Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by ... -
A biomimetic multi-layered collagen-based scaffold for osteochondral repair
O'BRIEN, FERGAL (2014)Cartilage and osteochondral defects pose a significant challenge in orthopedics. Tissue engineering has shown promise as a potential method for the treatment of such defects; however, a long-lasting repair strategy has yet ... -
A collagen hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates
O'BRIEN, FERGAL (2014)An emerging paradigm in orthopedics is that a bone-healing outcome is the product of the anabolic (bone-forming) and catabolic (bone-resorbing) outcomes. Recently, surgical and tissue engineering strat- egies have emerged ... -
Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.
O'BRIEN, FERGAL (2014)Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate ... -
Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds.
O'BRIEN, FERGAL (2011)Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this in mind, we sought to determine the effects of crosslinking on both the ... -
The Development of Non-Viral Gene-Activated Matrices for Bone Regeneration Using Polyethyleneimine (PEI) and Collagen-Based Scaffolds
O'BRIEN, FERGAL; DUFFY, GARRY (2012)The healing potential of scaffolds for tissue engineering can be enhanced by combining them with genes to produce gene-activated matrices (GAMs) for tissue regeneration. We examined the potential of using polyethyleneimine ... -
In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells
O'BRIEN, FERGAL (2011)Background: Bone grafts are required to repair large bone defects after tumour resection or large trauma. The availability of patients?U? own bone tissue that can be used for these procedures is limited. Thus far bone ... -
Innovations in gene and growth factor delivery systems for diabetic wound healing
O'BRIEN, FERGAL; Laiva, Ashang Luwang; Keogh, Michael B. (2017)The rise in lower extremity amputations due to nonhealing of foot ulcers in diabetic patients calls for rapid improvement in effective treatment regimens. Administration of growth factors (GFs) are thought to offer an ... -
Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
O'BRIEN, FERGAL (2010)Artificial tissue growth requires cells to proliferate and differentiate within the host scaffold. As cell function is governed by mechano-sensitive selection, tissue type is influenced by the microscopic forces exposed ... -
Mesenchymal stem cell fate is regulated by the composition and mechanical properties of Collagen Glycosaminoglycan scaffolds
O'BRIEN, FERGAL (Elsevier, 2012)In stem cell biology, focus has recently turned to the influence of the intrinsic properties of the extracellular matrix (ECM), such as structural, composition and elasticity, on stem cell differentiation. Utilising ... -
A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
O'BRIEN, FERGAL (2010)Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold. Yet, causal relationships linking scaffold strain magnitudes and inlet fluid velocities to specific cell ... -
Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
O'BRIEN, FERGAL (2011)Although osteoporosis reduces overall bone mass causing bone fragility, recent studies report that the remaining bone tissue is significantly stiffer. Preliminary studies indicate that alterations in bone tissue mineral ... -
Staphylococcus aureus Protein A Binds to Osteoblasts and Triggers Signals That Weaken Bone in Osteomyelitis.
O'BRIEN, FERGAL; FOSTER, TIMOTHY; MIAJLOVIC, HELEN (2011)Osteomyelitis is a debilitating infectious disease of the bone. It is predominantly caused by S. aureus and is associated with significant morbidity and mortality. It is characterised by weakened bones associated with ... -
Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen GAG scaffold
O'BRIEN, FERGAL (2010)Anchorage dependent cells respond to mechanical and physical properties of biomaterials. One such cue is a material?s mechanical stiffness. We compared the osteogenic potential of collagen glycosaminoglycan (CG) scaffolds ...