Micromechanical mass sensors for biomolecular detection in a physiological environment
Citation:
Braun, T., Barwich, V., Ghatkesar, M.K., Bredekamp, A.H., Gerber, Ch., Hegner, M., Lang, H.P., Mass sensors for biomolecular detection in physiological environment, Physical Review E, 72, 2005, 031907Download Item:
Abstract:
Micromechanical cantilever arrays are used to measure time-resolved adsorption of tiny masses based on
protein-ligand interactions. Here, streptavidin-biotin interactions are investigated in a physiological environment.
A measurement method is introduced using higher flexural modes of a silicon cantilever in order to
enhance the sensitivity of mass detection. Modeling the cantilever vibration in liquid allows the measurement
of absolute mass changes. We show time-resolved mass adsorption of final 7?0.7 ng biotinylated latex beads.
The sensitivity obtained is about 2.5 pg/Hz measuring at a center frequency of 750 kHz.
Author's Homepage:
http://people.tcd.ie/hegnermDescription:
PUBLISHED
Author: HEGNER, MARTIN
Type of material:
Journal ArticleCollections
Series/Report no:
Physical Review E;72;
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