| dc.contributor.author | CONNON, STEPHEN | en |
| dc.contributor.author | GRAYSON, DAVID | en |
| dc.contributor.author | POWER, DAVID PATRICK | en |
| dc.date.accessioned | 2010-08-17T15:47:13Z | |
| dc.date.available | 2010-08-17T15:47:13Z | |
| dc.date.issued | 2010 | en |
| dc.date.submitted | 2010 | en |
| dc.identifier.citation | David P. Power, Olivier Lozach, Laurent Meijer, David H. Grayson, Stephen J. Connon, Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones, Bioorganic & Medicinal Chemistry Letters, 20, 16, 2010, 4940-4944 | en |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | A remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing 9-azapaullone and its protonated, N-oxidised and N-alkylated derivatives. Screening studies identified an active and strongly selective inhibitor of CDK9/cyclin T | en |
| dc.format.extent | 4940-4944 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Bioorganic & Medicinal Chemistry Letters | en |
| dc.relation.ispartofseries | 20 | en |
| dc.relation.ispartofseries | 16 | en |
| dc.rights | Y | en |
| dc.subject | Biochemistry | en |
| dc.subject | Cyclin Dependent Kinases | en |
| dc.title | Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/connons | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/dgrayson | en |
| dc.identifier.rssinternalid | 67227 | en |
| dc.subject.TCDTheme | Cancer | en |
| dc.subject.TCDTheme | Neuroscience | en |
| dc.identifier.rssuri | http://dx.doi.org/10.1016/j.bmcl.2010.06.024 | en |
| dc.contributor.sponsor | Higher Education Authority (HEA) | en |
| dc.identifier.uri | http://hdl.handle.net/2262/40480 | |
