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dc.contributor.authorREILLY, RICHARDen
dc.contributor.authorKIISKI, HANNIen
dc.contributor.authorNOLAN, HUGHen
dc.contributor.authorWHELAN, ROBERTen
dc.date.accessioned2010-10-17T16:29:50Z
dc.date.available2010-10-17T16:29:50Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationWhelan R, Lonergan R, Kiiski H, Nolan H, Kinsella K, Bramham J, O'Brien M, Reilly RB, Hutchinson M, Tubridy N, A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 121, 9, 2010, 1420-1426en
dc.identifier.issn1388-2457en
dc.identifier.otherYen
dc.descriptionPUBLISHEDen
dc.description.abstractObjective. To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). Methods. Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive (SPMS) patients, and 21 controls) completed visual and auditory oddball tasks while data were recorded from 134 EEG channels. Latency and amplitude differences, calculated using composite mean amplitude measures, were tested using an ANOVA. Topographical differences were tested using statistical parametric mapping (SPM). Results. In the visual modality, P2, P3 amplitudes and N2 latency were significantly different across groups. In the auditory modality, P2, N2, and P3 latencies and N1 amplitude were significantly different across groups. There were no significant differences between RRMS and SPMS patients on any ERP component. There were topographical differences between MS patients and controls for both early and late components for the visual modality, but only in the early components for the auditory modality. PASAT score correlated significantly with auditory P3 latency for MS patients. Conclusions. There were significant ERP differences between MS patients and controls. Significance. The present study indicated that both early sensory and later cognitive ERP components are impaired in MS patients relative to controls.en
dc.description.sponsorshipThis study was partly funded by an Enterprise Ireland grant to R. Reilly (eBiomed: eHealthCare based on Biomedical Signal Processing and ICT for Integrated Diagnosis and Treatment of Disease)en
dc.format.extent1420-1426en
dc.language.isoenen
dc.relation.ispartofseriesClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiologyen
dc.relation.ispartofseries121en
dc.relation.ispartofseries9en
dc.rightsYen
dc.subjectNeuroscienceen
dc.subjectMultiple sclerosisen
dc.titleA high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/reillyrien
dc.identifier.peoplefinderurlhttp://people.tcd.ie/whelanr3en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kiiskihen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/nolanh4en
dc.identifier.rssinternalid67519en
dc.identifier.doihttp://dx.doi.org/10.1016/j.clinph.2010.03.019en
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.clinph.2010.03.019en
dc.identifier.orcid_id0000-0001-8578-1245en
dc.contributor.sponsorEnterprise Irelanden
dc.identifier.urihttp://hdl.handle.net/2262/41102


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