dc.contributor.author | ROBERTSON, IAN | en |
dc.date | 2005 | en |
dc.date.accessioned | 2006-04-12T05:30:35Z | |
dc.date.available | 2006-04-12T05:30:35Z | |
dc.date.issued | 2005 | en |
dc.date.submitted | 2006-04-12T05:30:35Z | en |
dc.identifier.citation | Bellgrove MA, Hawi Z, Kirley A, Fitzgerald M, Gill M, Robertson IH `Association between dopamine transporter (DAT1) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder (ADHD)? in Neuropsychopharmacology, 30, (12), 2005, pp 2290 - 2297 | en |
dc.identifier.other | Y | en |
dc.description | PUBLISHED | en |
dc.description.abstract | A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated
with ADHD and has been linked to an enhanced response to methylphenidate (MPH).
One aspect of the attention deficit in ADHD includes a subtle inattention to left space,
resembling that seen after right cerebral hemisphere damage. Since left-sided
inattention in ADHD may resolve when treated with MPH, we asked whether leftsided
inattention in ADHD was related to DAT1 genotype and the therapeutic
efficacy of MPH. Forty-three ADHD children and their parents were genotyped for
the DAT1 3? VNTR polymorphism. The children performed the Landmark Test, a
well-validated measure yielding a spatial attentional asymmetry index (leftward to
rightward attentional bias). Parents rated their child?s response to MPH
retrospectively using a three-point scale (No, Mediocre or Very Good Response).
Additionally, parents used a symptom checklist to rate behaviour while on and off
medication. A within family control design determined whether asymmetry indices
predicted biased transmission of 10-repeat parental DAT1 alleles and/or response to
methylphenidate. It was found that left-sided inattention predicted transmission of the
10-repeat allele from parents to probands and was associated with the severity of
ADHD symptomatology. Children rated as achieving a very good response to MPH
displayed left-sided inattention, while those rated as achieving a poorer response did
not. Our results suggest a sub-group of children with ADHD for whom the 10-repeat
DAT1 allele is associated with left-sided inattention. MPH may be most efficacious
in this group because it ameliorates a DAT1-mediated hypodopaminergic state. | |
dc.format.extent | 119649 bytes | |
dc.format.extent | 2297 | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.rights | Y | en |
dc.subject | Psychology | en |
dc.title | Association between dopamine transporter (DAT1) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder (ADHD) | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.contributor.sponsor | Health Research Board | |
dc.identifier.uri | http://hdl.handle.net/2262/479 | |