The Scissors Model of Microcrack Detection in Bone: Work in Progress
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2010Citation:
David Taylor, Lauren Mulcahy, Gerardo Presbitero, Pietro Tisbo, Clodagh Dooley, Garry Duffy and Thomas Clive Lee, The Scissors Model of Microcrack Detection in Bone: Work in Progress, Materials Research Society Proceedings, 1274, 2010Download Item:
Abstract:
We have proposed a new model for microcrack detection by osteocytes in bone. According to this model, cell signalling is initiated by the cutting of cellular processes which span the crack. We show that shear displacements of the crack faces are needed to rupture these processes, in an action similar to that of a pair of scissors. Current work involves a combination of cell biology experiments, theoretical and experimental fracture mechanics and system modelling using control theory approaches. The approach will be useful for understanding effects of extreme loading, aging, disease states and drug treatments on bone damage and repair; the present paper presents recent results from experiments and simulations as part of current, ongoing research.
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Grant Number
Science Foundation Ireland (SFI)
08-FRP-ENM991
Author's Homepage:
http://people.tcd.ie/dtaylorhttp://people.tcd.ie/dooleycl
http://people.tcd.ie/gaduffy
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Science Foundation Ireland (SFI)Type of material:
Journal ArticleSeries/Report no:
Materials Research Society Proceedings1274
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Full text availableKeywords:
Bioengineering, Bone fractureSubject (TCD):
Next Generation Medical DevicesMetadata
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