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A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity

dc.contributor.authorDE SOUSA MENEZES, FABIOen
dc.date.accessioned2012-01-12T17:04:20Z
dc.date.available2012-01-12T17:04:20Z
dc.date.issued2012en
dc.date.submitted2012en
dc.identifier.citationNiko Radulović, Nevenka Đorđević, Marija Denić, Mariana Martins Gomes Pinheiro, Patricia Dias Fernandes, Fabio Boylan, A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity, Food and Chemical Toxicology, 50, 2, 2012, 274 279en
dc.identifier.otherYen
dc.descriptionPUBLISHEDen
dc.description.abstract2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin?s strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20 mg/kg). It was found to be lethal in doses higher than 20 mg/kg.en
dc.description.sponsorshipThe authors from Serbia acknowledge funds received from the Ministry of Science and Technological Development of Serbia (Project 172061). The authors are grateful to the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, grant support and fellowship to PDF), Fundac?o Carlos Chagas Filho de Apoio a Pesquisa do Estado do Rio de Janeiro (FAPERJ, grant support to PDF). FB is grateful to the Start up grant No. 51002.516.R01336 from Trinity College Dublin.en
dc.format.extent274-279en
dc.language.isoenen
dc.relation.ispartofseriesFood and Chemical Toxicologyen
dc.relation.ispartofseries50en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectPharmacologyen
dc.subjectConium maculatum Len
dc.subject2-pentylpiperidineen
dc.subjectVolatile alkaloiden
dc.titleA novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activityen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/desouzafen
dc.identifier.rssinternalid75588en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeInternational Developmenten
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.fct.2011.10.060en
dc.identifier.urihttp://hdl.handle.net/2262/61641


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