Browsing School of Engineering by Author "Prendergast, Patrick"
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A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study
Prendergast, Patrick (2005)Bone undergoes continuous remodeling in response to mechanical loading. However, the underlying mechanisms by which bone cells respond to their changing mechanical environment, that is, strain in the load-bearing matrix ... -
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
Prendergast, Patrick; CAMPBELL, VERONICA; FARRELL, ERIC; BYRNE, ELAINE (2007)Adult mesenchymal stem cells (MSCs) have the capability to differentiate along several lineages including those of bone, cartilage, tendon and muscle, thus offering huge potential for the field of tissue engineering. The ... -
Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents.
Prendergast, Patrick; LENNON, ALEXANDER; KELLY, DANIEL; BOYLE, COLIN; EARLY, MICHAEL; LALLY, CAITRIONA (2010)The design of medical devices could be very much improved if robust tools were available for computational simulation of tissue response to the presence of the implant. Such tools require algorithms to simulate the response ... -
Computer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesis
Prendergast, Patrick (2011)Computational modelling is becoming ever more important for obtaining regulatory approval for new medical devices. An accepted approach is to infer performance in a population from an analysis conducted in an idealized or ... -
Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint
Prendergast, Patrick; Murphy, Paula (University of Edinburgh (datashare), 2011)Muscle contractions begin in early embryonic life, generating forces that regulate the correct formation of the skeleton. In this paper we test the hypothesis that the biophysical stimulation generated by muscle forces may ... -
Identification of mechanosensitive genes during skeletal development: Alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways
MORRIS, DEREK; KELLY, DANIEL; Prendergast, Patrick; ROLFE, REBECCA (2014)Background Mechanical stimulation is necessary for regulating correct formation of the skeleton. Here we test the hypothesis that mechanical stimulation of the embryonic skeletal system impacts expression levels of genes ... -
Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos.
Prendergast, Patrick; Murphy, Paula (University of Edinburgh (datashare), 2011)Very little is known about the regulation of morphogenesis in synovial joints. Mechanical forces generated from muscle contractions are required for normal development of several aspects of normal skeletogenesis. Here we ... -
Mechanobiology of embryonic limb development
Prendergast, Patrick; NOWLAN, NIAMH CATHERINE; MURPHY, PAULA (2007)Considerable evidence exists to support the hypothesis that mechanical forces have an essential role in healthy embryonic skeletal development. Clinical observations and experimental data indicate the importance of muscle ... -
Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach
Prendergast, Patrick; CHECA ESTEBAN, SARA (2010)Mechanical stimuli are one of the factors that influence tissue differentiation. In the development of biomaterials for bone tissue engineering, mechanical stimuli and formation of a vascular network that transport oxygen ... -
Stresses in peripheral arteries following stent placement: a finite element analysis
Prendergast, Patrick; KELLY, DANIEL; LALLY, CAITRIONA (2009)The success of stents to restore blood flow in atherosclerotic peripheral arteries is low relative to coronary arteries. It has been shown that joint flexion induces a mechanical environment that makes stent placement in ...