Browsing School of Engineering by Author "Prendergast, Patrick John"
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Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage
KELLY, DANIEL; Prendergast, Patrick John (Springer, 2007)The aim of this study was to determine whether or not biochemical markers can be used as surrogate measures for the mechanical quality of tissue engineered cartilage. The biochemical composition of tissue engineered ... -
Biomechanics of ossiculoplasty
KELLY, DANIEL; Prendergast, Patrick John (Rila, 2003)Many different designs of prostheses are available for middle ear surgery. Clinical comparisons of such prostheses are often difficult because of the large number of variables involved in the clinical outcome; including ... -
Bone tissue material properties are altered during osteoporosis
Prendergast, Patrick John (Hylonome, 2005)Measurement of the effects of osteoporosis on the mechanical behavior of bone has been performed using whole bone testing, or testing of volumes of ovariectomized cancellous bone1-3 and these studies revealed a decrease ... -
Dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones
MURPHY, PAULA; NOWLAN, NIAMH CATHERINE; Prendergast, Patrick John (Elsevier, 2007) -
Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis
KELLY, DANIEL; Prendergast, Patrick John (Springer, 2004)The structure and functionality of tissue-engineered cartilage is determined by the tissue culture conditions and mechanical conditioning during growth. The quality of tissue-engineered cartilage can be evaluated using ... -
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
Prendergast, Patrick John; O'BRIEN, FERGAL (IOS Press, 2007)The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing ... -
The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses
KELLY, DANIEL; Prendergast, Patrick John (Wolters Kluwer, 2003)Hypothesis: We hypothesize that the differences in the bioacoustic performance of ossicular replacement prosthesis designs, and insertion positions, can be quantified using finite element analysis. Background: Many ... -
Evolution of mechanoregulation of bone growth will lead to non-optimal bone phenotypes
NOWLAN, NIAMH CATHERINE; Prendergast, Patrick John (Elsevier, 2005) -
The influence of ventilation tube design on the magnitude of stress imposed at the implant/tympanic membrane interface
KELLY, DANIEL; Prendergast, Patrick John (Elsevier, 2008)The design of ventilation tubes or grommets is thought to have a considerable influence on their performance. A computational model (finite element method) was used to investigate the significance of four design parameters ... -
Loss of trabeculae by mechano-biological means may explain rapid bone loss in osteoporosis.
Prendergast, Patrick John (2008)Osteoporosis is characterized by rapid and irreversible loss of trabecular bone tissue leading to increased bone fragility. In this study, we hypothesize two causes for rapid loss of bone trabeculae; firstly, the perforation ... -
Mechanics applied to skeletal ontogeny and phylogeny
Prendergast, Patrick John (Springer, 2002)The musculo-skeletal system serves the mechanical function of creating motion and transmitting loads. It is made up mainly of four components: bone, cartilage, muscle and fibrous connective tissue. These have evolved over ... -
Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects
KELLY, DANIEL; Prendergast, Patrick John (Elsevier, 2005)Cartilage defects that penetrate the subchondral bone can undergo spontaneous repair through the formation of a fibrous or cartilaginous tissue mediated primarily by mesenchymal stem cells from the bone marrow. This ... -
Modelling damage growth and failure in elastic materials with random defect distributions
LENNON, ALEXANDER BENEDICT; Prendergast, Patrick John (Royal Irish Academy, 2004)Failure in materials under cyclic loading occurs by the growth and propagation of cracks. If they are sufficiently numerous, the cracks can be considered to be continuously distributed in the material. In this paper, a ... -
Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair
KELLY, DANIEL; Prendergast, Patrick John (Mary Ann Liebert, 2006)The optimal mechanical properties of a scaffold to promote cartilage generation in osteochondral defects in vivo are not known. During normal daily activities cartilage is subjected to large cyclic loads that not only ... -
Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period
KELLY, DANIEL; Prendergast, Patrick John (Springer, 2008)Mandibular symphyseal distraction osteogenesis is a common clinical procedure to modify the geometrical shape of the mandible for correcting problems of dental overcrowding and arch shrinkage. In spite of consolidated ...