dc.contributor.author | WINDLE, HENRY | |
dc.contributor.author | KELLEHER, DERMOT P | |
dc.date.accessioned | 2013-09-04T08:51:31Z | |
dc.date.available | 2013-09-04T08:51:31Z | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013 | en |
dc.identifier.citation | Queiroz, D.M.M., Harris, P.R., Sanderson, I.R., Windle, H.J., Walker, M.M., Rocha, A.M.C., Rocha, G.A., (...), Crabtree, J.E, Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study, PLoS ONE, 8, 7, 2013, art. no. e68833 | en |
dc.identifier.other | Y | |
dc.description | PUBLISHED | en |
dc.description.abstract | Objective:
Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in
developing countries. Whilst an association between
H. pylori
infection and ID/IDA has been proposed in the literature,
currently there is no consensus. We studied the effects of
H. pylori
infection on ID/IDA in a cohort of children undergoing
upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country.
Methods:
In total 311 children (mean age 10.7
6
3.2 years) from Latin America - Belo Horizonte/Brazil (n = 125), Santiago/
Chile (n = 105) - and London/UK (n = 81), were studied. Gastric and duodenal biopsies were obtained for evaluation of
histology and
H. pylori
status and blood samples for parameters of ID/IDA.
Results:
The prevalence of
H. pylori
infection was 27.7% being significantly higher (p
,
0.001) in Latin America (35%) than in
UK (7%). Multiple linear regression models revealed
H. pylori
infection as a significant predictor of low ferritin and
haemoglobin concentrations in children from Latin-America. A negative correlation was observed between MCV (r =
2
0.26;
p = 0.01) and MCH (r =
2
0.27; p = 0.01) values and the degree of antral chronic inflammation, and between MCH and the
degree of corpus chronic (r =
2
0.29, p = 0.008) and active (r =
2
0.27, p = 0.002) inflammation.
Conclusions:
This study demonstrates that
H. pylori
infection in children influences the serum ferritin and haemoglobin
concentrations, markers of early depletion of iron stores and anaemia respectively | en |
dc.description.sponsorship | This work was mainly funded by the Sixth Framework Program of the European Union, Project CONTENT (INCO-CT-2006-032136). Funds were also
provided by Conselho Nacional de Desenvolvimento Cient?
?
fico e Tecnololo
?
gico (CNPq), Brazil and by CONICYT/BM RUE
#
29 and FONDECYT
#
1100654, Chile.
DMMQ is funded under the Sixth Framework Program of the European Union, Project CONTENT (INCO-CT-2006-032136) and the Instituto Nacional de Cie
?
ncia e
Tecnologia/CNPq/Brazil, Instituto de Biomedicina do Semi-A
?
rido Brasileiro. JEC is funded under the Sixth Framework Program of the European Union, Project
CONTENT (INCO-CT-2006-032136). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the man
uscript | en |
dc.format.extent | art. no. e68833 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | PLoS ONE; | |
dc.relation.ispartofseries | 8; | |
dc.relation.ispartofseries | 7; | |
dc.rights | Y | en |
dc.subject.other | Medicine | |
dc.title | Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/kellehdp | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hjwindle | |
dc.identifier.rssinternalid | 87971 | |
dc.rights.ecaccessrights | OpenAccess | |
dc.identifier.uri | http://hdl.handle.net/2262/67353 | |