| dc.contributor.author | ROZAS, ISABEL | |
| dc.date.accessioned | 2014-01-07T13:28:38Z | |
| dc.date.available | 2014-01-07T13:28:38Z | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009 | en |
| dc.identifier.citation | S. Lopez, T. McCabe, R. S. McElhinney, T. B. H. McMurry, I. Rozas, Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution, Tetrahedron Letters, 50, 44, 2009, 6022-6024 | en |
| dc.identifier.other | Y | |
| dc.description | PUBLISHED | en_US |
| dc.description.abstract | 2-Amino-4,6-dichloro-5-nitropyrimidine is an intermediate required for the preparation of nitropyrimidines as inactivators of the DNA repairing protein MGMT. When attempting its synthesis 2-amino-4,5,6-trichloropyrimidine is obtained instead, via unusal aromatic substitution of the nitro group in the 2-amino-4-hydroxy-5-nitropyrimidin-6-one by chloride. The synthesis, the reactivity of 4,5,6-trichloropyrimidine and the efficient preparation of 2-amino-4,6-dichloro-5-nitropyrimidine are presented | en_US |
| dc.description.sponsorship | IRCSET | en_US |
| dc.format.extent | 6022-6024 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Tetrahedron Letters; | |
| dc.relation.ispartofseries | 50; | |
| dc.relation.ispartofseries | 44; | |
| dc.rights | Y | en |
| dc.subject | DNA | en_US |
| dc.title | Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/rozasi | |
| dc.identifier.rssinternalid | 64062 | |
| dc.rights.ecaccessrights | OpenAccess | |
| dc.identifier.uri | http://hdl.handle.net/2262/67767 | |
