Browsing RSS Feeds by Sponsor "Health Research Board"
Now showing items 21-40 of 86
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Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention.
(Elsevier, 2007)Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal ... -
Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8? and CD4CD8? Invariant Natural Killer T Cells
(2011)CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells ... -
Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children
(British Society for Immunology, 1998)Recent clinical trials have demonstrated that new generation acellular pertussis vaccines can confer protection against whooping cough. However, the mechanism of protective immunity against Bordetella pertussis infection ... -
Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1
(The American Society for Biochemistry and Molecular Biology, 2000)We have found that lethal toxin from Clostridium sordellii, which specifically inactivates the low molecular weight G proteins Ras, Rap, and Rac, inhibits the activation of p38 mitogen-activated protein kinase (MAPK) by ... -
The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses
(Wolters Kluwer, 2003)Hypothesis: We hypothesize that the differences in the bioacoustic performance of ossicular replacement prosthesis designs, and insertion positions, can be quantified using finite element analysis. Background: Many ... -
Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes.
(Taylor and Francis, 1995)Bromodeoxyuridine incorporation is a useful method for studying the pattern of DNA synthesis in proliferating cells. The distribution pattern of incorporated BrdU in villus enterocytes of duodenal explants was analysed ... -
Electrocardiogram based neonatal seizure detection
(IEEE, 2007)A method for the detection of seizures in the newborn using the electrocardiogram (ECG) signal is presented. Using a database of eight recordings, a method was developed for automatically annotating each 1-min epoch as ... -
Endothelin inhibitors for advanced prostate cancer
(John Wiley, 2011)This is the protocol for a review and there is no abstract. The objectives are as follows: Our review aims to determine the effectiveness and adverse effects of endothelin inhibitors for advanced prostate cancer. The ... -
Estimation of coherence using the median is robust against EEG artefacts
(2017)Coherence is a mathematical measure of correlation in the frequency domain, commonly used to quantify the oscillatory synchrony of bio-signals such as the electroencephalogram (EEG). In biomedical applications, such as ... -
Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis
(The American Society for Microbiology, 1999)Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell ... -
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
(John Wiley, 2008)BACKGROUND?Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folaterelated genes associated with ... -
Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
(Wiley-Blackwell, 2009)Candida albicans is more pathogenic than Candida dubliniensis. However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two ... -
Identifying strategies to maximise recruitment and retention of practices and patients in a multicentre randomised controlled trial of an intervention to optimise secondary prevention for coronary heart disease in primary care.
(BioMed Central, 2009)BACKGROUND: Recruitment and retention of patients and healthcare providers in randomised controlled trials (RCTs) is important in order to determine the effectiveness of interventions. However, failure to achieve recruitment ... -
IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65
(The American Society for Biochemistry and Molecular Biology, 2006)The members of the NF-?B transcription factor family are key regulators of gene expression in the immune response. Different combinations of NF-?B subunits not only diverge in timing to induce transcription but also recognize ... -
Impact of the MTHFR C677T polymorphism on risk of neural tube defects:case-control study
(BMJ, 2004)Homozygosity for the T allele of the C677T polymorphism of the gene encoding the folate dependent enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is a risk factor for neural tube defects.1 Both the homozygous (TT) ... -
Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?
(BMJ, 1996)BACKGROUND: Activation of circulating T lymphocytes results in expression of HLA-DR, interleukin-2 receptor (IL-2R), transferrin receptor (TrR), and decreased amounts of surface CD3. AIM: To examine the activation status ... -
Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram.
(Association for Research in Vision and Ophthalmology, 2008)PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake ... -
The influence of environment, predisposing, enabling and need variables on personal health choices of adults with intellectual disability.
(2013)Attention to disease and risk factor management is increasingly a feature of people with intellectual disability (ID) as an augmented life expectancy also exposes a growing number of age-related diseases. An additional ... -
Interleukin-1 activates transcription factor NF kappa B in glial cells
(Portland Press, 1993)Recombinant human interleukin-1 (IL-1) alpha and beta were found to activate a latent cytosolic form of the transcription factor NF kappa B in rat C6 glioma. IL-1 beta was 10 times more potent than IL-1 alpha for this ... -
Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells
(American Society for Microbiology, 1996)Using a murine respiratory infection model, we have demonstrated previously that infection with Bordetella pertussis or immunization with a whole-cell pertussis vaccine induced antigen-specific Th1 cells, which conferred ...