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Now showing items 61-80 of 86
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Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
(American Society for Biochemistry and Molecular Biology, 2002)Interleukin-1 (IL-1) activates p38 MAP kinase via the small G protein Ras, and this activity can be down-regulated by another small G protein Rap. Here we have further investigated the role of Ras and Rap in p38 MAPK ... -
Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes
(Massachusetts Medical Society, 2008)Background Duplications and deletions in the human genome can cause disease or predispose persons to disease. Advances in technologies to detect these changes allow for the routine identification of submicroscopic imbalances ... -
Reduced azole susceptibility in genotype 3 C. dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression.
(2005)Candida dubliniensis is a recently identified yeast species primarily associated with oral carriage and infection in HIV-infected individuals. The species can be divided into at least four genotypes on the basis of the ... -
Regional Variation in Electroconvulsive Therapy Use
(2011)Although electroconvulsive therapy (ECT) is the most powerful treatment for depression, substantial variability in use has been described in Ireland. The Mental Health Commission collects usage data from approved centres ... -
Regulatory T cells: friend or foe in immunity to infection.
(Nature, 2004)Homeostasis in the immune system is dependant on a balance between responses that control infection and tumours and the reciprocal responses that prevent inflammation and autoimmune diseases. It is now recognized that ... -
Replication of an Association of a Promoter Polymorphism of the Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder
(Elsevier, 2009)Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The ... -
Response variability in Attention Deficit Hyperactivity Disorder: evidence for neuropsychological heterogeneity
(2007)Response time (RT) variability is a common finding in ADHD research. RT variability may reflect frontal cortex function and may be related to deficits in sustained attention. The existence of a sustained attention deficit ... -
RNAi of COL1A1 in mesenchymal progenitor cells
(Nature Publishing Group, 2004)Given that mutant COL1A1 is known to cause Osteogenesis Imperfecta (OI), tools to modulate COL1A1 expression are likely to be of significant therapeutic value. In this context, we have evaluated RNA interference (RNAi) as ... -
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
(The American Society for Biochemistry and Molecular Biology, 2005)It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory ... -
ROSIE (Research Outcome Study, Evaluating Drug Treatment Effectiveness) Baseline Data Report .
(National Advisory Committee on Drugs, 2007) -
Sensitivity of Photoreceptor-Derived Cell Line (661W) to Baculoviral p35, Z-VAD.FMK, and Fas-Associated Death Domain
(Association for Research in Vision and Ophthalmology, 2002)PURPOSE: Rod, cone, cone-rod, and macular dystrophies eventually bring about the death of cone photoreceptor cells. The present study explores means of inhibiting apoptosis in addition to inducing a specific apoptotic ... -
Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
(Society of Leukocyte Biology, 1998)Interleukin-1 (IL-1) is a central regulator of the immune and inflammatory responses. Recently, significant advances have been made in the area of IL-1 receptors and IL-1 signal transduction. A family of proteins has been ... -
Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.
(2009)The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate ... -
The SPHERE Study. Secondary prevention of heart disease in general practice: a randomised controlled trial of tailored practice and patient care plans with parallel qualitative, economic and policy analyses.
(BioMed Central, 2005)BACKGROUND: The aim of the SPHERE study is to design, implement and evaluate tailored practice and personal care plans to improve the process of care and objective clinical outcomes for patients with established coronary ... -
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
(Portland Press, 1997)Protein kinase C (PKC) has been implicated in interleukin 1 (IL1) signal transduction in a number of cellular systems, either as a key event in IL1 action or as a negative regulator. Here we have examined the effects of ... -
The Subiculum: What It Does, What It Might Do, And What Neuroanatomy Has Yet To Tell Us
(Anatomical Society of Great Britain and Ireland, 2005)The subiculum is a pivotal but under-investigated structure positioned between the hippocampus proper and entorhinal and other cortices, as well as a range of subcortical structures. The subiculum has a range of ... -
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
(2009)Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to ... -
Synthesis, Biochemical and Molecular Modelling Studies of Antiproliferative Azetidinones causing Microtubule Disruption and Mitotic Catastrophe
(Elsevier, 2011)The structure-activity relationships of antiproliferative ?-lactams, focusing on modifications at the 4-position of the ?-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger ... -
Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
(The American Association of Immunologists, 2003)Signaling through Toll-like receptors (TLR) activates dendritic cell (DC) maturation and IL-12 production, which directs the induction of Th1 cells. We found that the production of IL-10, in addition to inflammatory cytokines ...