Browsing RSS Feeds by Author "HARRIS, JAMES"
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Autophagy and cytokines
(2011)Autophagy is a highly conserved homoeostatic mechanism for the lysosomal degradation of cytosolic constituents, including long-lived macromolecules, organelles and intracellular pathogens. Autophagosomes are formed in ... -
Autophagy in the immune response to tuberculosis: clinical perspectives
(2011)A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator ... -
How tumour necrosis factor blockers interfere with tuberculosis immunity.
(John Wiley, 2010)Tumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) ... -
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
(Elsevier, 2009)Autophagy is a recently recognized immune effector mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ... -
Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis
(University of Chicago, 2008)umor necrosis factor (TNF)?? is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the pathogenesis of rheumatoid ...
