Browsing RSS Feeds by Author "NAKAGOME, SHIGEKI"
Now showing items 1-6 of 6
-
Ancestral polymorphisms and sex-biased migration shaped the demographic history of brown bears and polar bears.
NAKAGOME, SHIGEKI (2013)Recent studies have reported discordant gene trees in the evolution of brown bears and polar bears. Genealogical histories are different among independent nuclear loci and between biparentally inherited autosomal DNA (aDNA) ... -
Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation.
NAKAGOME, SHIGEKI (2012)Risk alleles for complex diseases are widely spread throughout human populations. However, little is known about the geographic distribution and frequencies of risk alleles, which may contribute to differences in disease ... -
Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.
NAKAGOME, SHIGEKI (2014)Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific ... -
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
NAKAGOME, SHIGEKI (2016)The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to ... -
Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.
NAKAGOME, SHIGEKI (2016)The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system. The present study examines patterns of ... -
Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae.
NAKAGOME, SHIGEKI (2008)Evolution of the bear family Ursidae is well investigated in terms of morphological, paleontological, and genetic features. However, several phylogenetic ambiguities occur within the subfamily Ursinae (the family Ursidae ...