Browsing RSS Feeds by Subject "T cell activation"

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    • Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. 

      Long, Aideen; Petrovic, Danijela; Stamataki, Zania; Dempsey, Eugene; Golden-Mason, Lucy; Freeley, Michael; Doherty, Derek; Prichard, David; Keogh, Catherine; Conroy, Jennifer; Mitchell, Siobhan; Volkov, Yuri; McKeating, Jane A.; O'Farrelly, Cliona; Kelleher, Dermot (2011)
      T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ...

    • IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections. 

      Mc Loughlin, Rachel; Leech, John M.; Lacey, Keenan A.; Mulcahy, Michelle E.; Medina, Eva (2017)
      IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ...