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Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation
(2022)The lager yeasts, Saccharomyces pastorianus, are hybrids of Saccharomyces cerevisiae and Saccharomyces eubayanus and are divided into two broad groups, Group I and II. The two groups evolved from at least one common ... -
Packing a punch: Understanding how flavours are produced in lager fermentations
(2021)Beer is one of the most popular beverages in the world and it has an irreplaceable place in culture. Although invented later than ale, lager beers dominate the current market. Many factors relating to the appearance (colour, ... -
Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples
(2021)Candida tropicalis is a human pathogen that primarily infects the immunocompromised. Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in 2009, there have been no large-scale, multi-isolate ... -
Transcriptional Profile of the Industrial Hybrid Saccharomyces pastorianus Reveals Temperature-Dependent Allele Expression Bias and Preferential Orthologous Protein Assemblies
(2021)Saccharomyces pastorianus is a natural yeast evolved from different hybridization events between the mesophilic S. cerevisiae and the cold-tolerant S. eubayanus. This complex aneuploid hybrid carries multiple copies of the ... -
A Novel Method to Identify and Characterise Peptide Mimotopes of Heat Shock Protein 70-associated antigens
(2006)The heat shock protein, Hsp70, has been shown to play an important role in tumour immunity. Vaccination with Hsp70-peptide complexes (Hsp70-PCs), isolated from autologous tumour cells, can induce protective immune responses. ... -
The complex and dynamic genomes of industrial yeasts
(2009)The Saccharomyces sensu stricto genus contains many species that are industrially important for fermentation of wines, beers and ales. The molecular characterization of the genomes of yeasts involved in these processes ... -
Recombination Sites on Hybrid Chromosomes in S. pastorianus share Common Sequence Motifs and define a Complex Evolutionary Relationship between Group I and II Lager Yeasts
(2017)Saccharomyces pastorianus, referred to as lager yeasts, are hybrids of S. cerevisiae and S. eubayanus. Isolates within the species are divided into two groups (I and II) based on chromosome structure and composition. ... -
Fermentation innovation through complex hybridization of wild and domesticated yeasts
(2019)The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid ... -
Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
(2022)One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation ... -
Development of an intertidal foraminifera training set for the North Sea and an assessment of its application for Holocene sea-level reconstructions
(2021)Regional datasets of the vertical distribution of intertidal foraminifera are useful to reconstruct Holocene sea-level changes from fossil foraminifera in estuaries and salt marshes. In this paper, we present a new ... -
The peripheral cannabinoid receptor type 1 (CB1) as a molecular target for modulating body weight in man
(2021)The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted central side effects of both agonists (in wasting disorders) or antagonists (in obesity and diabetes) have limited their therapeutic ... -
Direct measurement of the contribution of street lighting to satellite observations of nighttime light emissions from urban areas
(2021)Nighttime light emissions are increasing in most countries worldwide, but which types of lighting are responsible for the increase remains unknown. Also unknown is what fraction of outdoor light emissions and associated ... -
Optimization of Zn-Mn ferrite nanoparticles for low frequency hyperthermia: Exploiting the potential of superquadratic field dependence of magnetothermal response
(2022)Magnetothermal applications of nanoparticles in biomedicine are currently limited by low thermal responses to oscillating magnetic fields on one side and by detrimental physiological effects of electromagnetic radiation ... -
Internet-Delivered Interventions for Depression and Anxiety Symptoms in Children and Young People: A Systematic Review and Meta-analysis.
(2022)Background: Mental health difficulties in children and adolescents are highly prevalent; however, only a minority receive adequate mental health care. Internet-delivered interventions offer a promising opportunity to ... -
"Home is wherever Hongkongers are": Narratives of emigration and exile by pro-democracy Hongkongers.
(2022)Hong Kong has seen a huge wave of emigration in recent months due to the ongoing regime repression in the city since the 2019 mass protests. As an indication, by September, 2021, 88,000 Hongkongers have submitted resettlement ... -
On the incorporation of universal human rights values into an "everyday" healthcare ethics: a spiritual perspective
(2021)Background: The Universal Declaration of Human Rights adopted in Geneva in December 1948 has been part of a key set of documents framing universal human rights values and informing ethical practices in many spheres. Legal ... -
On-site energy generation in the manufacturing industry: effects on the variability of the net electricity demand
(2020)Local distribution system operators (DSOs) are currently dealing with the unpredictability and high variability of energy production coming from an increasing number of distributed variable renewable energy (VRE) systems. ... -
Single-pulse all-optical partial switching in amorphous DyxCo1-xand TbxCo1-xwith random anisotropy
(2022)Repeated uniform switching of the magnetization of thin films of ferrimagnetic amorphous Gdx (FeCo)1 x in response to single fast laser pulses is well established. Here, we report unusual toggle switching in thin films ... -
Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
(2021)Medicinal plants have been used for a very long time to improve human health; they are gaining increasing popularity globally as drugs, complementary and alternative medicines, food supplements, cosmetics and, more surprisingly, ... -
Spatio-temporal variability in the deposition of beach-cast kelp (wrack) and inter-specific differences in degradation rates
(2021)Coastal habitats dominated by marine macroalgae typically exhibit high rates of pri- mary productivity and play a key role in local and regional carbon cycles and stores. In temperate regions, large brown algae (i.e. ...
