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Now showing items 261-280 of 13947
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Energy Analysis of Fleet Operations using Green Liquid Hydrogen and Synthetic Sustainable Aviation Fuel
(2023)Aircraft designs are changing more rapidly than ever, due to the disruptive technology revolution required to curb harmful emissions, and meet stringent climate targets. As a result, the role of conceptual design tools is ... -
On-Surface Synthesis of Polyphenylene Wires Comprising Rigid Aliphatic Bicyclo[1.1.1]Pentane Isolator Units
(2023)Bicyclo[1.1.1]pentane (BCP) motifs are of growing importance to the pharmaceutical industry as sp3 -rich bioisosteres of benzene rings and as molecular building blocks in materials science. Herein we explore the behavior ... -
A Heterometallic Porphyrin Dimer as a Potential Quantum Gate: Magneto-Structural Correlations and Spin Coherence Properties
(2023)In the development of two-qubit quantum gates, precise control over the intramolecular spin-spin interaction between molecular spin units plays a pivotal role. A weak but measurable exchange coupling is especially important ... -
Health data to support local communities
(Trinity College Dublin, 2024)The Robert Emmet Community Development Project (CDP) highlighted community concerns with health problems among residents of Oliver Bond House, work done to describe building issues, and difficulties in having these issues ... -
Genomics Tools to Study Membrane-Based Systems
(2024)The learning objectives of this chapter are the following: - Designing an experimental plan for omics-based study for membrane-based systems - Omics tools to investigate microbial communities of membrane-based systems - ... -
Supramolecular Chirogenesis in a Sterically Hindered Porphyrin: A Critical Theoretical Analysis
(2023)Invited for the cover of this issue are the groups of Irina Osadchuk at Tallinn University of Technology and Mathias Senge at Trinity College Dublin. The image depicts how a porphyrin with two guest molecules (R)-camphor ... -
Structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole, another ostensible by-product in the synthesis of geminal-dimethyl hydrodipyrrins
(2023)The crystal structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluenesulfonyl)-1H-pyrrol-2-yl]-1,3-dinitrobutan-2-yl}-1-(4-toluenesulfonyl)-1H-pyrrole (1, C26H24Br2N4O8S2) is presented. The title compound was isolated ... -
Strapped Porphyrins as Model Systems for Atropisomeric Photosensitizer Drugs
(2023)The time dependence of atropisomer interconversion has limited the pursuit of single atropisomer drug candidates, even in circumstances where one atropisomer presents favorable biological activity over another. Moderate ... -
The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre-clinical and Clinical Developments in the Last Decade†‡
(2023)This review follows the research, development and clinical applications of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC, temoporfin) in photodynamic (cancer) therapy (PDT) and other medical applications. ... -
Structures of S-(pyridin-2-yl) 4-nitrobenzothioate, S-(pyridin-2-yl) 4-methylbenzothioate and S-(pyridin-2-yl) 4-methoxybenzothioate: building blocks for low-symmetry multifunctional tetrapyrroles
(2023)The crystal structures of three S-(pyridin-2-yl) benzothioesters with varying para-phenyl substituents are presented, namely, S-(pyridin-2-yl) 4-nitrobenzo-thioate (1, C12H8N2O3S), S-(pyridin-2-yl) 4-methylbenzothioate (2, ... -
The role of aromaticity in the cyclization and polymerization of alkyne-substituted porphyrins on Au(111)
(2023)Aromaticity is an established and widely used concept for the prediction of the reactivity of organic molecules. However, its role remains largely unexplored in on-surface chemistry, where the interaction with the substrate ... -
Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia
(2014)Leukemia is an immediately life-threatening cancer wherein immature blood cells are overproduced, accumulate in the bone marrow (BM) and blood and causes immune and blood system failure. Treatment with chemotherapy can ... -
Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds
(2011)Cord blood expansion ex vivo can be achieved in liquid suspension through the addition of cytokines at the expense of often undesirable cell differentiation. In order to derive a cytokine-free dynamic culture system, we ... -
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia
(2010)Acute myeloid leukaemia (AML) is a cancer of haematopoietic cells that develops in three-dimensional (3-D) bone marrow niches in vivo. The study of AML has been hampered by lack of appropriate ex vivo models that mimic ... -
There's no such thing as cycle traffic: a critical discourse analysis of public opposition to pro-cycle planning
(2024)Across a variety of low-cycling contexts, there are ambitious targets to reduce private car use and increase cycling to decarbonise everyday mobility practices. A component of many plans to achieve this modal shift is ... -
An exploration of hygiene poverty in Ireland
(School of Social Work & Social Policy, TCD, 2023) -
Comment on “A new approach to stabilization of calcareous dune sand”
(2023)The Discussers read with interest the paper by Ghadr et al. (2022) (the Authors); the research topic being particularly important for various regions of the world regarding the main goals of dust suppression and wind-driven ... -
Effect of chitin, chitosan and NaCMC biopolymers on the consistency limits of organic silt
(2024)With global concerns on carbon emissions, there is increased need for various eco-friendly alternatives to conventional (cement and lime) additives used in ground improvement applications. This paper investigates the ... -
Predicting the Compactability of Artificially Cemented Fine‑Grained Soils Blended with Waste‑Tire‑Derived Aggregates
(2023)This study investigates the possibility of extending the specific gravity ratio (SGR) modeling framework, originally developed for predicting the compaction properties of unamended fine-grained soils (with no binder) ...
