RSS Feeds: Recent submissions
Now showing items 561-580 of 13947
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Practical Synchronization for OTFS
(2023)In the existing literature on joint timing and frequency synchronization of orthogonal time frequency space modulation (OTFS), practically infeasible impulse pilot with large peak-to-average power ratio (PAPR) is deployed. ... -
Acoustic plate-valve resonator for low-frequency sound absorption
(2023)An acoustic plate-valve resonator is developed and optimized to maximize absorption by enhancing the Helmholtz resonance with coincident structural vibrations of the plate-valve. The current research initially examines the ... -
Residential Long-Term Care and the Built Environment: Balancing Quality of Life and Infection Control
(2023)Objectives: This article explores expert insights into residential long-term care (RLTC), specifically regarding the built environment, its impact on infection control (IC) measures and on resident, staff, and family ... -
A Data Literate Ireland: The Case for a Whole-of-Government Approach to Data Literacy Skills Development in Ireland
(2022)Data literacy is broadly defined as “the ability to read, work with, analyse, and argue with data.” The Open Data Institute highlights that data literacy goes beyond the technical skills of working with data, emphasising ... -
Debunked: Data Literacy For Adults Evaluation Report
(ADAPT, the SFI Research Centre for AI-Driven Digital Content Technology, 2023)ADAPT is a world-leading Science Foundation Ireland Research Centre for AI-Driven Digital Content Technology. ADAPT has a dedicated team for Education and Public Engagement (EPE), which aims to inspire the Irish public ... -
Turkish version of the SHARE-Frailty Instrument for primary care: reliability and validity in the nursing home setting
(2023)In Turkey, physical frailty instruments have not been studied in the nursing home setting. We determined the reliability and validity of a Turkish version of the SHARE-Frailty Instrument for primary care (SHARE-FI) in ... -
In Transit? Documenting the lived experiences of welfare, working and caring for one-parent families claiming Jobseeker's Transitional Payment
(2023)This research, conducted in conjunction with One Family, set out to document the lived experiences of Jobseeker’s Transitional Payment (JST) recipients and to explore how JST is working ‘on the ground’. Because JST is ... -
Many Unions, One Estimate? Disaggregating the Currency Union Effect on Trade
(2023)A large literature estimates the impact of currency unions on trade. Often ignored in these estimates are the dramatic differences in the characteristics of countries adopting common currencies, hidden by aggregation ... -
Performance of a Closed Cycle Power Takeoff for a Shore-Based Wave Energy Device
(2023)A promising class of devices for ocean wave energy conversion is called the oscillating water column in which the wave power is transferred to an airflow that rotates a turbine. A closed cycle power takeoff (CCPTO), in ... -
RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models
(2023)Age-related macular degeneration (AMD) is the most common cause of blindness in the aged population. However, to date there is no effective treatment for the dry form of the disease, representing 85–90% of cases. AMD is ... -
Molecular inversion probe-based sequencing of ush2a exons and splice sites as a cost-effective screening tool in ush2 and arrp cases
(2021)A substantial proportion of subjects with autosomal recessive retinitis pigmentosa (arRP) or Usher syndrome type II (USH2) lacks a genetic diagnosis due to incomplete USH2A screening in the early days of genetic testing. ... -
Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction
(2023)AAV gene therapy for ocular disease has become a reality with the market authorisation of LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III clinical ... -
MFRP -Associated Retinopathy and Nanophthalmos in Two Irish Probands: A Case Report
(2022)The conjunction of nanophthalmos (NO) and retinitis pigmentosa (RP) provides challenges to effective clinical management while narrowing the genetic spectrum for targeted molecular diagnostics. This case study describes ... -
siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model
(2021)Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impair ment. Previous work has shown that ... -
Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction
(2020)Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically associated with Dominant Optic Atrophy ... -
Optical genome mapping and revisiting short-read genome sequencing data reveal previously overlooked structural variants disrupting retinal disease-associated genes
(2023)Purpose: Structural variants (SVs) play an important role in inherited retinal diseases (IRD). Although the identification of SVs significantly improved upon the availability of genome sequencing, it is expected that ... -
Using single molecule Molecular Inversion Probes as a cost-effective, high-throughput sequencing approach to target all genes and loci associated with macular diseases
(2022)Macular degenerations (MDs) are a subgroup of retinal disorders characterized by central vision loss. Knowledge is still lacking on the extent of genetic and nongenetic factors influencing inherited MD (iMD) and age-related ... -
AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice
(2022)Recombinant adeno-associated virus (AAV) vectors are one of the main gene delivery vehicles used in retinal gene therapy ap proaches; however, there is a need to further improve the effi cacy, tropism, and safety of these ... -
Work like a Doc: A comparison of regulations on residents' working hours in 14 high-income countries
(2023)Background: Medical residents work long, continuous hours. Working in conditions of extreme fatigue has adverse effects on the quality and safety of care, and on residents' quality of life. Many countries have attempted ... -
The PRESTO report. Sustainability and Resilience in the Irish Health System
(Trinity College Dublin/London School of Economics/Partnership for Health System Sustainability & re, 2023)The recovery of the Irish health system from the COVID-19 pandemic provides an opportunity for reflection and learning. COVID-19 has tested health systems in the extreme and spotlighted long- standing weaknesses. This ...
