School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 261-280 of 668
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Understanding the role of low glass transition temperature excipients in the mitigation of amorphisation on mechanical processing
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Commonly employed pharmaceutical processes such as milling, blending and compaction may unintentionally lead to the generation of amorphous regions or metastable polymorphic forms in crystalline active pharmaceutical ... -
The production and characterization of fluoroquinolone amorphous solid dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Ciprofloxacin (CIP) is a Biopharmaceutics Classification System class 4 drug, which exhibits solid-state limited solubility. Among the different formulation options available to improve the solubility of such a compound, ... -
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration on different anticoagulant modalities
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Uncertainty remains concerning pharmacokinetics (PK) of antimicrobials in critically ill patients due to the scarcity of data and the variable physiology of the patient cohort. This project incorporates two distinct aims. ... -
Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed ... -
Development of novel cyclodextrins as non-viral gene delivery vectors and assessment of differentiated cell culture models to predict in vivo gene expression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The aims of this thesis were to examine the use of differentiated cell culture systems in the in vitro assessment of non-viral gene delivery systems and to investigate the use of commercial and novel cyclodextrins as vectors ... -
Stereoselective synthesis of novel tubulin inhibitors with diverse functionality for integration into molecular conjugates and designed multiple ligands
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The principal objective of the work described in this thesis was the synthesis of a series of novel tubulin inhibitors, with defined stereochemistry and diverse functionality, suitable for the formation of molecular ... -
Factors affecting the pharmacotherapeutic management of chronic non-malignant pain in ageing and elderly populations in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Chronic non-malignant pain (CNMP) has emerged as a global health priority due to the prevalence, complexity and presentation of the condition across all age- groups, social classes and ethnicities. There is a high prevalence ...
