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Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells

Horan, Jason (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)

Isoquinolines are naturally occurring alkaloids that have shown biological activity in a number of different areas. In terms of breast cancer, tetrahydroisoquinoline based compounds have shown potential as selective estrogen ...

The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues

Greene, Thomas F. (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)

Combretastatin A-4 (CA4) is a natural product first isolated from the Combretum caffrum South African willow tree by Pettit and co-workers. CA4 has proved to be a potent antimitotic agent, with a mechanism of action ...

Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors

Egan, Billy (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)

Breast cancer is the second most common cancer in Ireland and accounts for 28% of all cancers in women in Ireland, with an average of 1726 new diagnosis each year. One of the major therapeutic advances in clinical treatment ...

Pharmaceutical Chemistry: Recent submissions

Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells

The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues

Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors

Development of the beta-lactam structure as a scaffold for biologically active compounds

Studies in the design and synthesis of novel selective serotonin reuptake inhibitors

Synthesis of intermediates for carbapenem antibiotics and synthetic analogues of dehydroepiandrosterone (DHEA)

Design and synthesis of novel isoquinoline monoamineoxidase inhibitors

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Pharmaceutical Chemistry: Recent submissions

Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells ﻿

The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues ﻿

Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors ﻿

Development of the beta-lactam structure as a scaffold for biologically active compounds ﻿

Studies in the design and synthesis of novel selective serotonin reuptake inhibitors ﻿

Synthesis of intermediates for carbapenem antibiotics and synthetic analogues of dehydroepiandrosterone (DHEA) ﻿

Design and synthesis of novel isoquinoline monoamineoxidase inhibitors ﻿

Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells

The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues

Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors

Development of the beta-lactam structure as a scaffold for biologically active compounds

Studies in the design and synthesis of novel selective serotonin reuptake inhibitors

Synthesis of intermediates for carbapenem antibiotics and synthetic analogues of dehydroepiandrosterone (DHEA)

Design and synthesis of novel isoquinoline monoamineoxidase inhibitors