Browsing Trinity College Dublin, the University of Dublin: Theses & Dissertations by Title
Now showing items 4614-4633 of 6412
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Regulation of cancer stem cell differentiation by genes and microRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Since the discovery of a stem cell phenotype in cancer, specific tumour cells with this phenotype, often called cancer stem cells (CSCs), are now widely accepted as the progenitors of oncogenesis, proliferation, treatment ... -
Regulation of expression of transcription factors nuclear factor-kappa B and early growth response-1 by Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)The Gram-negative bacterium Helicobacter pylori colonizes the human gastric epithelium and is a causative agent of peptic ulcer disease and gastric adenocarcinoma. Although H. pylori colonization is associated with gastric ... -
Regulation of innate and adaptive immune responses by synthetic and pathogen-derived immunomodulatory molecules
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The development of new and improved vaccine formulations for human use requires the discovery of efficacious non-toxic adjuvants that enhance immune responses to poorly immunogenic purified native or recombinant antigens. ... -
Regulation of innate and adaptive immunity by the vaccine adjuvant alum
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)While many licensed vaccines consist of whole or inactivated pathogens, there is a move toward vaccines based on purified antigens which although safer are generally less immunogenic and therefore require adjuvants to ... -
Regulation of the immunomodulatory cytokine IL-10 by Twist2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Dysregulation of cytokines can lead to infectious and inflammatory diseases. The anti-inflammatory cytokine IL-10 is known to control pro-inflammatory cytokines such as TNF-a, IL-6 and IL-12. The regulation of IL-10 is ... -
Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to development of oesophageal adenocarcinoma (OAC), through a premalignant lesion, Barrett's oesophagus (BO). OAC has a 5-year survival of patients ... -
Regulatory T cell induction and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production ... -
Rehabilitation of Awareness of Deficits in Patients with Acquired Brain Injury: Applying a User-friendly Computerised Intervention Approach
This dissertation consists of three studies that examined the phenomenon of emergent awareness following acquired brain injury. Despite the putative influence that impaired emergent awareness can have on rehabilitation ... -
Reimaging Heroes and Villains: Contested and Changing Representations of the Republican Historical Figures in Mainland China
(Trinity College Dublin. School of Histories & Humanities. Discipline of History, 2024)This thesis examines the diverse and contested representations of Republican historical figures in mainland China. This research project was designed to discuss public history in mainland China, particularly how histories ... -
REIMAGINING THE PUBLIC SPHERE: ADDRESSING THE CRISES OF DEMOCRACY THROUGH APPLIED DRAMA
(Trinity College Dublin. School of Creative Arts. Discipline of Drama, 2022)Liberal democracy is under threat and in a state of crisis around the world. This crisis of democracy is characterised by a rise in right-wing populism, an increase in political strongmen, and an undermining of liberal ... -
The Relation between the What-It-Is and the Why-It-Is in Aristotle's Posterior Analytics, On the Parts of Animals, and Metaphysics
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Philosophy, 2020)In this dissertation, I wish to examine the relation between the what-it-is and the why-it-is in Aristotle’s three treatises. The main conclusions I will defend in this thesis can be formulated as follows. In the Posterior ... -
The relationship between childhood depression, obesity and poor school performance among urban disadvantaged children
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2018)The Relationship between Childhood Depression, Obesity and Poor School Performance among Urban Disadvantaged Children Prakashini Banka Background: Despite the recent emergence of literature establishing the prevalence of ... -
The Relationship Between Problematic Appearance Comparisons on Social Media, Self-Compassion and Body Dissatisfaction
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2021)Body dissatisfaction is a prevalent and problematic issue among young adults and adolescents and can be heightened with social media use. However, little is known about precisely how social media influences the appearance ... -
Relationship between the molecular interaction and the structure of the bent core liquid crystals in the nematic phase
(Trinity College (Dublin, Ireland). Department of Electronic & Electrical Engineering, 2012)The relationship between the molecular interaction and the molecular structure of the bent core mesogens in the nematic phase is investigated in detail. Various physical phenomena are observed and interpreted. -
Relationship-based social work : a 'thirdspace' in responding to trauma
(Trinity College (Dublin, Ireland). School of Social Work and Social Policy, 2015)This practitioner research study explores people’s lived experience of trauma leading to their engagement with the social work service of a hospital emergency department. It further explores the elements of responsive ... -
Relationships between dementia risk and protective lifestyle factors with cognition and brain function in midlife
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2023)It is now acknowledged that Alzheimer's disease (AD) neuropathology is present decades before the onset of clinical symptoms. Midlife is a critical period for the beginning of AD pathology and potentially a unique ... -
Relationships between identity and attitudes to the achievement of native speaker norms in adult L2 learners of Irish
(Trinity College (Dublin, Ireland). Centre for Language and Communication Studies, 2014)This study examines how attitude, motivation and identity in adult learners of Irish are related to awareness of and commitment to different dialects and varieties of the language as learning targets. Specifically, it is ... -
Relative dose / exposure to air pollutants between modes of transport, while commuting to work in Dublin
(Trinity College (Dublin, Ireland). Department of Civil, Structural and Environmental Engineering, 2008)Research was carried out into the relative exposure of commuters to air pollutants in Dublin between four modes of transport. These differences were determined experimentally by simultaneously sampling the personal exposure ... -
Relativism about truth : a critique
(Trinity College (Dublin, Ireland). Philosophy Department, 2012)This thesis examines John MacFarlane's attempt to make sense of relative truth, but concludes by rejecting the coherence of such an attempt, on the grounds that it fails to adequately address a problem that was posed by ... -
A reliabilist-teleological account of Plato's theory of knowledge based on the Timaeus, the Republic and the Theaetetus
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Philosophy, 2023)Whether, in Plato's epistemology, the Forms can be grasped without using the inferior epistemic capacities, and whether the inferior epistemic capacities contribute to one's grasp of F-ness and the Form F - These are the ...