Browsing Trinity College Dublin, the University of Dublin: Theses & Dissertations by Title
Now showing items 4714-4733 of 6412
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The Role of Exercise Prehabilitation Prior to Oncological Resection
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)Cancer is characterised by uncontrolled cell growth within the body. Surgical resection is the primary curative treatment for solid tumours. However, surgery is invasive and associated with significant morbidity and ... -
The Role of Financial Markets in Incentivising Corporate Social and Environmental Performance
(Trinity College Dublin. School of Business. Discipline of Business & Administrative Studies, 2022)The central topic of this thesis is the role played by financial markets in incentivising firms to alter their impact on society through non-market strategies relating to environmental and social performance. The thesis ... -
The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Major depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which ... -
Role of Fusobacterium nucleatum-oral keratinocyte interactions in the progression of oral dysplasia and Oral Squamous Cell Carcinoma
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2023)Dysplastic changes of the oral epithelium have a potential for malignant transformation. Several studies have identified increased abundance of Fusobacterium spp. on malignant and premalignant oral lesions. The potential ... -
The role of GPR55 in neuronal and immune cell signalling and function
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)The orphan G-protein coupled receptor, GPR55, is widely expressed throughout the body and is responsive to cannabinoids. However, its endogenous ligand is believed to be L-a-lysophosphatidylinositol (LPI). GPR55 is expressed ... -
The role of helminth parasites in host invasion: a freshwater fish system
(Trinity College Dublin. School of Natural Sciences. Discipline of Zoology, 2021)With the incidence of species invasions set to increase in the coming decades, it is increasingly important that research on invasive species impacts captures the complexity of natural ecosystems, including the influence ... -
The role of IL-1 and Type I IFN in CNS function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Cytokines including interleukins (ILs) and interferons (IFNs) are induced in response to tissue injury, infection or inflammation. Peripheral cytokines signal to the healthy Central Nervous System (CNS) to produce ... -
Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ... -
The role of innate lymphocyte metabolism in sepsis
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2020)Sepsis is the result of a dysregulated systemic immune response to microbial infection that leads to organ failure and death in about 30% of affected individuals. The antimicrobial response is biphasic with an overwhelming ... -
Role of kynurenine on platelet's function and beyond
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase enzyme in other tissues. Although it has been shown that ... -
The Role of Light Variation in the Attending to and Memorisation of Stained-Glass Windows: An Eye Tracking and Behavioural Study.
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2024)Stained-glass is a distinctive art form that both transmits and reflects light, making it a desirable medium for research on the effects of light on attention and memory. There have been few investigations exploring the ... -
Role of membrane lipids and plasma lipoproteins in the regulation of activated protein C function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)Activated protein C (APC) is an important anticoagulant factor that serves to downregulate thrombin generation. APC also has several cytoprotective properties, including anti-apoptotic and endothelial barrier stabilizing ... -
The Role of miR-155 in Myeloid cells during Experimental Autoimmune Encephalomyelitis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterised by multifocal demyelinating lesions with associated neuronal damage. Although MS is a CD4+ T cell-mediated disease, ... -
The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. Our laboratory has reported evidence ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ... -
The role of nutrition as a determinant of clinical, immunological and pharmacological outcome in HIV-infected children in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Introduction: Perinatally acquired HIV infection and malnutrition remain major public health challenges for sub-Saharan Africa health systems. HIV and malnutrition result in 50% mortality. The introduction of antiretroviral ... -
The Role of Physical Activity for Patients with Advanced Cancer
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2019)Abstract The aim of this thesis was to explore the role of physical activity for people living with advanced stages of cancer. The use of both a quantitative and qualitative elements in this thesis enabled a thorough ... -
The Role of Political Parties in Civil War Peace Processes Outside Their Own Country - A New Internationalism? A Case Study of Sinn Féin and its Involvement in Three Foreign Peace Processes
(Trinity College Dublin. School of Religion. Irish School of Ecumenics, 2023)The existing literature on third party involvement in peace processes has largely overlooked the role of foreign political parties. This qualitative research tackles this gap by examining the involvement of foreign political ... -
Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs)
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ... -
The role of self and identity in motivating learners of Mandarin Chinese as a foreign language in Ireland
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. C.L.C.S., 2018)This thesis investigates the role of self and identity in the learning motivation of Mandarin Chinese. The number of participants is 92. Employing theories from sociology, social psychology and applied linguistics, the ...