Browsing Trinity College Dublin, the University of Dublin: Theses & Dissertations by Title
Now showing items 4734-4753 of 6412
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The Role of STAT3 in the Pathogenesis of Chronic Lymphocytic Leukaemia
Chronic Lymphocytic Leukaemia (CLL) is characterized by the accumulation of CD5/19+ B cells in the blood, bone marrow and lymph nodes. The tumour microenvironment of the bone marrow and secondary lymphoid organs promotes ... -
The role of the biophysical cues on the initiation, progression and maintenance of a chondrogenic phenotype in human stem cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Articular Cartilage Tissue Engineering (AC TE) is a promising strategy for the treatment of small cartilage defects, however complete mimicry of the native tissue remains a significant challenge. Mechanical cues like dynamic ... -
Role of the Elongator complex in innate immune responses of macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The innate immune system functions as the first line of defence against pathogen infection. Innate immune systems are functionally present across the animal kingdom and mediate host defence against infection via a myriad ... -
The role of the Locus Coeruleus-Noradrenergic system integrity in the main Dementia modifiable risk factors: a comparative approach linking neuropsychological measures to biological and lifestyle indices
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2023)Dementia etiopathogenesis is characterised by a plethora of heterogeneous and diverse factors, which contribute to delay the definition of effective treatments and preventing strategies. Growing evidence identifies in the ... -
The role of tissue-resident memory T cells in immunity to Bordetella pertussis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Whooping cough (pertussis) is a severe respiratory disease cause by the Gram-negative bacterium Bordetella pertussis. Despite high vaccine coverage, a resurgence of pertussis has been observed over recent years. Although ... -
The role of vitamin D and UVB on the risk and survival of oesophageal and gastric cancer
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2018)The Role of Vitamin D and UVB on the Risk and Survival of Oesophageal and Gastric Cancer By Fiona O?Sullivan Background: Vitamin D is a fat-soluble vitamin which has many sources. Currently, there are numerous ways in ... -
Role of von Willebrand factor glycans in modulating susceptibility to ADAMTS13 proteolysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet tethering at sites of vascular injury. VWF adhesive function is dependent upon multimeric composition, which is regulated in plasma by ... -
The Role of Women in Post Conflict Peace building in Niger Delta
(Trinity College Dublin. School of Religion. Irish School of Ecumenics, 2020)United Nations Security Council Resolution 1325, passed in October 2000, emphasizes the crucial role of women in the prevention and resolution of conflicts. It urges UN member states to recognize the gendered nature of ... -
The roles of cytoplasmic aspartate aminotransferase in trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017) -
Romanesque chevron ornament
(Trinity College (Dublin, Ireland). Department of History of Art and Architecture, 2001)Chevron ornament was one of the most common forms of architectural decoration during the twelfth century, in particular in Normandy, England and Ireland, and is found in smaller concentrations throughout Europe during the ... -
Rorty On Religion
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Philosophy, 2020)This thesis aims to explore Rorty's pragmatic approach to religion and critically engage with it. In the core of this approach lies his distinction between private and public projects, and his plea for the privatization ... -
Routine health surveillance data: a 21-year quantitative cross-sectional study of first-time opioid addiction treatment among older adults
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2019)Introduction: Current literature identifies older people who use opioids as a neglected population. Little is known about temporal changes, treatment demand or treatment discharge outcomes among this population. Aim: This ... -
Royal religious commissions as political propaganda in Spain under Charles III (1759-1788)
(Trinity College (Dublin, Ireland). Department of History of Art and Architecture, 2000)This thesis examines the development of religious painting in Spain in the second half of the 18th century as a tool of political propaganda in the hands of a royal patron, Charles III. The period under study begins with ... -
RUC to PSNI : a study of radical organisational change
(Trinity College (Dublin, Ireland). Trinity Business School, 2009)This aim of this thesis is explore and explain the process of organisational change which saw the Royal Ulster Constabulary become the Police Service of Northern Ireland. The research approach adopted was process based, ... -
Run-Time Discovery, Selection, Composition & Invocation of Web Services using Semantic Descriptions
(Trinity College Dublin. Department of Computer Science, 2004-09)Web Service computing is enabled by using an architecture that provides interoperability between disparate and diverse applications. One goal of Web Services is to facilitate inter-organisational distributed computing using ... -
Running at the Devil with God's word. The pamphlets of the Early-Reformation preacher, Jacob Strauss
(Trinity College (Dublin, Ireland). Department of History, 2010)This thesis examines the printed pamphlets of a preacher of the early German Reformation, Jacob Strauss. The analysis is based primarily on my translations from German of Strauss's pamphlets; manuscript evidence from the ... -
Ruthenium Polypyridyl Complexes for Biological Applications in Imaging and as Anti-Cancer Agents
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)Ruthenium-polypyridyl complexes containing extended aromatic ring systems exhibit attractive photophysical properties and have been shown to bind strongly to DNA. Such properties make complexes like these suitable for a ... -
Ruthenium(11) metal complexes for photodynamic therapy (PDT) or as imaging agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Photodynamic therapy (PDT) represents a new localised method of treatment in cancer. The therapeutic effect is mediated by the generation of reactive oxygen species (ROS) and/or the formation of singlet oxygen (1 O2), a ... -
Ruthenium(II)-1,8,-Naphthalimide conjugates as DNA probes and photoreagents
(Trinity College (Dublin, Ireland). School of Chemistry, 2008)This thesis entitled "Ru(II)-1,8-Naphthalimide Conjugates as DNA Probes and Photoreagents" is divided into seven chapters. Chapter 1, the introduction, details the structure of DNA and the different modes by which small ... -
Ryegrass organelle genomes : phylogenomics and sequence evaluation
(Trinity College (Dublin, Ireland). Department of Botany, 2010)Perennial ryegrass (Lolium perenne L.) is the most important forage grass of temperate regions of the world. The main objective in breeding perennial ryegrass cultivars is to increase its biomass. Chloroplasts and ...