Browsing Trinity College Dublin, the University of Dublin: Theses & Dissertations by Title
Now showing items 833-852 of 6403
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C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ... -
C-reactive protein as a prognostic factor in cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Prognostication, the prediction of future outcomes, is a key aspect of cancer care but remains imprecise. An elevated serum C-reactive protein (CRP) is associated with high symptom burden, poor quality of life and shorter ... -
C. S. Lewis : the artist as educator
(Trinity College (Dublin, Ireland). School of Education, 2001)C.S. Lewis has received the critical attention primarily of theologians and literary critics who have focused on his work as a scholar, critic, novelist and apologist. This thesis offers a new focus for his writings. It ... -
C5L2, a nonsignalling C5A receptor is uncoupled to G proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory ... -
C6 glioma neuronal interactions and their moderation by the tryptophan-kynurenine metabolism pathway
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Brain glia possess the rate limiting enzyme indoleamine 2, 3-dioxygenase (IDO) which catalyses the conversion of tryptophan to kynurenine. Microglia also express kynurenine monooxygenase (KMO) and kynureninase (KYNU) which ... -
A cadaveric dissection study of the anatomical variations of the ureter and implications for surgical intervention
(Trinity College Dublin. School of Medicine. Discipline of Anatomy, 2019)A cadaveric dissection study of the anatomical variations of the ureter and implications for surgical intervention Joan M. Costelloe The importance of studying ureteric anatomy such that it can be applied to surgical ... -
Caesarean section in nulliparous women: a mixed methods study of factors influencing decision-making and outcomes for women - the MAMMI Study Caesarean Section Strand
Background: Caesarean section (CS) rates are on a rise over the last number of decades with increased postpartum morbidities, and limited understanding of factors that influence decision-making for CS. Understanding ... -
Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy ) : a role for dopamine
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Co-administration of caffeine profoundly enhances the acute toxicity of the substituted amphetamine 3, 4-methylenedioxymethamphetamine (MDMA “Ecstasy”) in rats, evidenced by high body temperature, tachycardia and increased ... -
The Calendar and the Scop: Beowulf as an Example of Anglo-Saxon Discourses on Time
(Trinity College Dublin. School of English. Discipline of English, 2020)In this thesis, I analyse Beowulf as a self-reflexive poem on time based on representations of time in the Anglo-Saxon period. The question of time transcends the long-standing issue of the dialectic relationship between ... -
Calix[4]arene-based hosts for lanthanide and anion binding : synthesis and physical studies.
(Trinity College (Dublin, Ireland). School of Chemistry, 2007)This thesis, entitled "Calix[4]arene-based hosts for lanthanide and anion binding: synthesis and physical studies" is divided into five chapters. Chapter 1 provides an introduction to the chemistry of calix[4]arenes, an ... -
Call Admission Control and Dynamic Pricing in a GSM/GPRS Cellular Network
(Trinity College (Dublin, Ireland). School of Computer Science & Statistics, 2004-09)In the past decade, the wireless communications market has experienced tremendous growth, and this growth is likely to continue in the near future. In addition to an increase in the number of users, ever more demanding ... -
Calvin and humanism
(Trinity College (Dublin, Ireland). Department of History, 2003)Calvin and humanism is an extensive and controversial topic the treatment of which depends to a considerable extent on the type of approach and method adopted. The introduction provides an overview of the special difficulties ... -
Campaign Spending and Electoral Integrity: Assessing the Plausibility of the Challenger Spending Efficacy Advantage in Irish & British Elections
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Political Science, 2020)Do incumbents lose ground to challengers even when their spending is evenly matched? Much of the literature points to a spending efficacy advantage for challengers (i.e. non-incumbents glean more from spending than ... -
Can the systematic use of non-invasive biomarkers in patients with lower gastrointestional sysmtpoms help rationalise the demand for limited endoscopy resources?
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Introduction: Gastrointestinal complaints are very common in the general population. Demand for endoscopy continues to outstrip capacity, despite significant annual increase in the number of endoscopies performed nationwide, ... -
Can you mold, handle or portray it? Iconicity and metaphor in depiction strategies in co-speech gesture
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. C.L.C.S., 2022)The study explores iconicity and metaphor revealed in various gestural depiction strategies in co-speech representational gestures (Kendon, 2004; David McNeill, 1992). The gesture examples have been sourced from three ... -
Cancer Cachexia - Prevalence and Predictors in Treatment-naive Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Title: Cancer Cachexia Prevalence and Predictors in Treatment-naïve Patients Candidate Name: Dr Niamh O Donoghue Background Cancer cachexia is a common wasting syndrome, yet it remains poorly understood and under-recognised. ... -
Cancer cell bioenergetics in response to anti-cancer agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Altered metabolism is a hallmark of cancer (Hanahan and Weinberg, 2011) and while genetic and molecular modifications have enabled cancers to survive the onslaught of various cancer therapies (Pillai et al., 2010), changes ... -
Cancer cell-platelet interactions in ovarian cancer metastasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ... -
Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ... -
Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ...