Trinity College Dublin, the University of Dublin: Theses & Dissertations: Recent submissions
Now showing items 21-40 of 6403
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'how like death they are!': Death and Childhood in the Novels of Charles Dickens
(Trinity College Dublin. School of English. Discipline of English, 2024)This thesis studies the intersection between eighteenth- and nineteenth-century discourses on childhood and Victorian attitudes towards death in the moribund child of Charles Dickens's novels. By the nineteenth century, ... -
The Testament of Stone: Understanding the past, present, and future cultural significance of the long lives of the Irish high crosses.
(Trinity College Dublin. School of Histories & Humanities. Discipline of History Of Art, 2024)The Irish High Crosses are a unique group of monuments that, relative to their size, convey a exceptional amount of information about the early Christian period in which they were made. Over the past one hundred and fifty ... -
Expert-Free Online Transfer Learning in Multi-Agent Reinforcement Learning
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2024)Reinforcement Learning (RL) enables an intelligent agent to optimise its performance in a task by continuously taking action from an observed state and receiving a feedback from the environment in form of rewards. RL ... -
Nucleoside and Oligonucleotide Modification for Targeting the DNA Damage Repair Enzyme SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)The exonuclease SNM1A is a key enzyme involved in the repair of interstrand crosslinks, a highly cytotoxic form of DNA damage. As cells depleted in this enzyme display increased sensitivity to chemotherapeutic agents such ... -
High-resolution remote sensing data and machine learning approaches for mapping and monitoring habitats
(Trinity College Dublin. School of Natural Sciences. Discipline of Geography, 2024)The increasing decline in the status of habitats, mainly due to anthropogenic stressors, has spurred the development and implementation of many conservation-related legislation. This legislation involves mapping, a critical ... -
Neurons, networks, and behaviour: Investigating multiscale interactions between brain regions and their behavioural correlates
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2024)Understanding the interactions between different brain regions is vital for unravelling the complexities of brain disorders and brain functions such as cognition, behaviour, and memory. While previous investigations of ... -
Surface Studies of Niobium Oxides
(Trinity College Dublin. School of Physics. Discipline of Physics, 2024)In this thesis, two important niobium-oxygen systems are studied. The first system is the NbO "nanocrystal" termination of Nb(110). A new model to explain this structure based on a monolayer of oxygen covering the surface ... -
Genotypic and phenotypic insights into an Irish axial spondyloarthritis cohort
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Axial spondyloarthritis (AxSpA) encompasses a group of closely related chronic inflammatory conditions which primarily affect the lumbar spine. The prototypic presentation of the disease is ankylosing spondylitis, which ... -
Investigating the Impact of Non-Structural Proteins of Coronaviruses (CoVs), MERS-CoV & SARS-CoV-1, upon the antiviral Interferon-α JAK/STAT Pathway
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- 2) highlights the need for greater understanding of the immune evasion mechanisms used by CoVs to subvert antiviral responses. CoVs have ... -
Plate-type Acoustic Valve Resonator for, Low-frequency Sound Absorption
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2024)Plate-type acoustic metamaterials with deep-subwavelength thickness have generated considerable enthusiasm for addressing low-frequency noise. These metamaterials can be tailored to obtain high absorption efficiency by ... -
Exploring the impact of a parent-designed family literacy programme in a DEIS primary school on family literacy practices, home school-relationships and confidence
(Trinity College Dublin. School of Education. Discipline of Education, 2024)This doctoral research is set in an urban DEIS (Delivering Equality of Opportunity in Schools) band 1 primary school (a school at risk of educational disadvantage) in Ireland and explores family literacy, home-school ... -
A Developmental Systems Investigation of Language Development in the Context of Preterm Birth
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2024)Preterm birth (< 37 weeks gestation) affects approximately 10% of births worldwide and is a public health concern given the developmental risks that it poses (World Health Organisation, 2023). While preterm birth is ... -
Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
Investigating a role for SARM1 in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), represent a leading cause of incurable blindness worldwide. RP is a genetically inherited retinal degeneration ... -
Tumours have a sex: impact on the response of bladder cancer and lung adenocarcinoma to therapy
(Trinity College Dublin. School of Medicine. Discipline of Radiation Therapy, 2024)Background: The 23rd pair of chromosomes in humans is responsible for sex determination, in which humans are categorised as female (XX chromosomes) or male (XY chromosomes). While phenotypically, male and females are ... -
Characterisation of Microbial Biomat Development in Soil Treatment Units Receiving Domestic Effluent
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2024)Soil treatment units are an essential part on on-site wastewater treatment system. In Ireland there are approximately 500,000 on-site wastewater treatment systems with 87% configured as a septic tank followed by a soil ... -
Parent-Infant Sleep as Co-Occupation: A Meta-Ethnography of Parent Experiences and Perspectives
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Sleep is a key component of health and wellbeing for both adults and infants and has implications for daytime functioning and quality of life. Infants' sleep patterns in the first two years involve unpredictable, short ... -
Vicarious trauma among nurses working in addiction services and the role of leadership: a European mixed methods study
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2024)Background: The phenomenon of vicarious trauma (VT) has been the subject of considerable attention for over 30 years, but its impact on nurses in addiction services remains poorly understood, despite the established link ... -
Parent-Child Interaction and the Developmental Profile of Children following Neonatal Encephalopathy
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2024)Neonatal Encephalopathy (NE) is a clinical condition characterised by disturbed neurological functioning in newborn infants and is associated with unfavourable outcomes including developmental delay. It is estimated that ... -
The Oro-Nasal Cavity as an Endogenous Staphylococcal Reservoir for Diabetic Foot Ulcer Infections Investigated by Whole Genome-Sequencing and Disinfection of Debrided Foot Ulcer Tissues using Electrochemically-Activated Hypochlorous Acid Solution
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2024)Background and study purpose Type II diabetes mellitus is highly prevalent worldwide (approximately 6.3-10.5% of the global population), and in the population of the Republic of Ireland (9.5%), and continues to increase ...