Browsing Trinity College Dublin Theses & Dissertations by Title
Now showing items 5214-5233 of 6401
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T cells in experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Multiple sclerosis (MS) is an intlammatory, demyelinating disease of the central nervous system (CNS) that is both clinically and pathologically heterogeneous. Studies in experimental autoimmune encephalomyelitis (EAE), ... -
T. H. White: A Critical Biography
(Trinity College Dublin. School of English. Discipline of English, 2018)This thesis is a critical biography of the author T. H. White. My purpose is to define the influences on his work throughout his life and set him in the historical and cultural context of the period from the 1930s through ... -
Tadhg mac Gearóid Uí Rodaighe agus a mhuintir
(Trinity College (Dublin, Ireland). Department of Irish and Celtic Studies, 2004)Rinneadh an taighde ar an teidil réamhluaite trí mhórán lámhscríbhinní sna hinstitiúidí éagsúla, Is. TCD H. 6. 15. go príomha, a chóipeáil, de scríobh láimhe agus a iniúchadh go mion le linn na hoibre sin féin agus ina ... -
Tailored nitrogen-containing polyaromatics - from surfaces to stacks
(Trinity College (Dublin, Ireland). School of Chemistry, 2016)Chapter 1: This chapter gives a broad introduction to the subjects of graphene and nanographenes, which are discussed in subsequent chapters. Common methodologies for the synthesis of substituted polyphenylenes and ... -
Taking advantage of correlated information for energy-aware scheduling in the IoT: A deep reinforcement learning approach
(Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2020)Millions of battery-powered sensors deployed for monitoring purposes in a multitude of scenarios, e.g., agriculture, smart cities, industry, etc., require energy-efficient solutions to prolong their lifetime. When these ... -
Taking Liberties : entrepreneurial governance and gentrification in inner Dublin
(Trinity College (Dublin, Ireland). Department of Geography, 2008)This thesis is centrally concerned with the relationship between capital, the state and disadvantaged inner-city communities. The overall objective of this research is to review the structural forces underlying the recent ... -
A Tale of Two Heteronormative sites: Considering Militaries and (Video)Gaming
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Sociology, 2021)This thesis explores two sites that have traditionally been associated with heteronormative masculinity (militaries and videogames). Through the use of qualitative methodologies, it seeks to unearth and examine the ways ... -
Talking about space : the Spatial Reference System of Irish English
(Trinity College (Dublin, Ireland). Centre for Language and Communication Studies, 2015)This thesis has three central goals. The first is to establish a system for how people used to talk about space in previous studies of Irish English. This Is done through constructing a Spatial Reference System from extant ... -
The Taming of the Shrewd: A Reappraisal of the Interests of the Company as a Control on Directorial Autonomy
(Trinity College Dublin. School of Law. Discipline of Law, 2023)This thesis examines how differing conceptions of the company's interests can affect the autonomy of directors. This involves a comparative analysis across five common law jurisdictions: Ireland, the United Kingdom, Delaware, ... -
The Tamura Cycloaddition: Mechanism and Enantiocontrol
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)This thesis documents attempts to employ succinimide derivatives as ‘anhydride surrogates’ in the organocatalytic cycloaddition between aryl succinic anhydrides and various electrophiles previously developed in our research ... -
Tandem language learning on the Internet : theory, tool development and empirical exploration
(Trinity College (Dublin, Ireland). Centre for Language and Communication Studies, 2004)The objective of this thesis is to investigate and advance the use of electronic mail for tandem language learning. Earlier research raised the following primary issues. Firstly, there were some organizational problems ... -
Targeted bone remodelling : investigating the scissors model
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Bone is continually being removed and replaced through the actions of basic multicellular units (BMU). This constant upkeep is necessary to remove microdamage and thus maintain the integrity of the bone. Microdamage forms ... -
Targeting DNA : synthesis, biophysical and biochemical studies of new aminoalkyl derivatives of diphenyl guanidines and acridine
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Research on the design and synthesis of DNA targeting molecules is widespread. There are a number of diseases which are treated using DNA-targeting agents. DNA ligands have been shown to exhibit anticancer, antiprotozoal, ... -
Targeting glial B2-adrenoceptors for immunododulation & neuoprotection in a rat model of Parkinson's disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Neuro-inflammation is a key contributor to the pathogenesis of Parkinson’s disease (PD). Brain-resident microglia are dynamic cellular effectors of inflammation-mediated neurodegeneration in the Parkinsonian brain. Here ... -
Targeting Synthetic Advances in Extended Phenanthrene and Phenanthroline Systems
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)The work herein describes the synthesis of a number of extended phenanthrene and phenanthroline systems as ligands, their Ru(II) and Ir(III) metal complexes, nitrogen-substituted graphene nanoribbons (N-GNRs), and as ... -
Targeting the NMDA receptor/NO signalling pathway following L-α aminoadipic acid-induced astrocytic impairment and associated changes in the structural plasticity of neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)This investigation firstly aims to characterise the impact of astrocytic dysfunction on neurons in vitro, specifically the effects of L-α amino adipic acid (L-AAA)-induced astrocytic dysfunction on neurite outgrowth and ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective actions in an animal model of Parkinson's disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2015)Parkinson's disease (PD) is a common neurodegenerative disorder that is characterised by the selective loss of dopamine (DA) neurons within the substantia nigra pars compacta and results in reduced striatal DA input ... -
Targeting the prostate cancer metabolome with novel trojan horse compounds.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023)Prostate cancer (PCa) is the second most common cancer diagnosed in males worldwide, and the incidence of this disease is predicted to double globally by 2030. In Ireland, PCa accounts for nearly 16% of all invasive cancers ... -
Targeting the Sphingosine 1-Phosphate Axis as a Therapeutic Strategy in Krabbe's Disease: A Pre-Clinical Study.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Krabbe's disease (KD, globoid cell leukodystrophy) is a rare infantile neurodegenerative disorder, caused by the defective gene galc encoding the lysosomal hydrolase galactosylceramidase (GALC). A subsequent decreased ... -
TATUS A Ubiquitous Computing Simulator
(Trinity College Dublin. Department of Computer Science, 2004-09)?... we are trying to conceive a new way of thinking about computers in the world, one that takes into account the natural human environment and allows the computers themselves to vanish into the background? - Mark Weiser, ...