Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 1021-1040 of 7000
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Exploring Membrane Transporters in Lung Epithelial Cells: Drug-Transporter Interaction Analyses in Different In Vitro Models
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Over the last decade, the incidence of lung-related diseases such as asthma and chronic obstructive pulmonary disease and their associated morbidity have continuously risen. A heterogeneity in treatment response to commonly ... -
Machine Learned Compact Kinetic Models for Combustion
(Trinity College Dublin. School of Physics. Discipline of Physics, 2023)Chemical kinetic models are an essential component in the development and optimisation of combustion devices through their coupling to multi-dimensional simulations such as computational fluid dynamics (CFD). Due to the ... -
Athermalisation and Characterisation of High-OrderSurface Grating Lasers for Optical Communications
(Trinity College Dublin. School of Physics. Discipline of Physics, 2023)The semiconductor laser allows for the vast quantities of data that are transmitted over optical fibre each day. A simple device has transformed our lives. This transformation will continue in the coming decade where ... -
Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
A Usable Knowledge Graph Framework for Linking Health Events with Environmental Data
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2023)Environmental exposures transported across air, land and water can affect our health making us more susceptible to developing a disease. Researchers studying these health-environment interactions integrate and link multiple ... -
The Growth and Characterisation of Mn2Au Thin Films and Heterostructures
(Trinity College Dublin. School of Physics. Discipline of Physics, 2023)In this thesis, Mn2Au thin films and heterostructures are grown via molecular beam epitaxy. Mn2Au thin films are investigated on MgO (001) and Al2O3 (1102) substrates, and on Pt (111) seed layer grown on an Al2O3 (0001) ... -
Bias-cut justice: the legal pursuits of Isolde Pantulf, Hawise, Countess of Aumale, and Nicholaa de la Haye c. 1180-1216
(Trinity College Dublin. School of Histories & Humanities. Discipline of History, 2023)Isolde Pantulf, Hawise, countess of Aumale, and Nicholaa de la Haye were contemporaries navigating the justice system in thirteenth-century England primarily under the reign of King John. The following study traces key ... -
Optimization Models and Learning Algorithms for Slice Reservationin Virtualized Communication Networks
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2023)The surge of mobile users with increasing needs of data and services has brought a tremendous momentum to telecommunications. This revolution paves the way to the development of next generation mobile networks, able to ... -
Consolidated Foreign Wealth of Nations: Initial steps and novel estimates
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Economics, 2023)This thesis is made of three essays in International Macroeconomics. The central question these essays focus on is how to assess the international exposure of countries. The conventional approach uses the residence of the ... -
Identification of Anticoagulant Properties of Dimethyl Fumarate and 4-Octyl Itaconate via Suppression of the Macrophage Type I Interferon-Tissue Factor Axis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The host response to infection is characterized by activation of the innate immune and blood coagulation systems, which collectively detect, neutralize, and prevent dissemination of the invading pathogen, maintaining ... -
Role of Fusobacterium nucleatum-oral keratinocyte interactions in the progression of oral dysplasia and Oral Squamous Cell Carcinoma
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2023)Dysplastic changes of the oral epithelium have a potential for malignant transformation. Several studies have identified increased abundance of Fusobacterium spp. on malignant and premalignant oral lesions. The potential ... -
Ecosystem services and water quality of turloughs, a form of intermittent karst wetland
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2023)Ecosystem services (ES) can be defined as the conditions and processes through which natural ecosystems sustain and fulfil human life. These can be classified as provisioning, regulating, and cultural (water and raw material ... -
Advanced Nationalist Political Activity in Ireland 1910-1917
(Trinity College Dublin. School of Histories & Humanities. Discipline of History, 2023)This thesis examines the political, as opposed to military, activities of advanced nationalists in Ireland, including the Irish Volunteers, the Irish Republican Brotherhood, Sinn Fein, the labour movement, the women's ... -
Engineering innate immunology in cardiovascular disease models and regenerative medicine
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Heart failure is the leading cause of death worldwide with atherosclerosis and myocardial infarction remaining prominent causes. It is now widely accepted that the inflammatory response holds a key role in advancing both ... -
HUMAN RIGHTS PROOFING DIGITAL SURVEILLANCE TECHNOLOGIES: THE REFLEXIVE DST WUNDERKAMMER FOR CIVIL SOCIETY ORGANISATIONS
(Trinity College Dublin. School of Law. Discipline of Law, 2023)I have explored in this thesis how Digital Surveillance Tech (DST) can be human rights proofed in areas of privacy to help emancipate vulnerabilised communities. Human rights proofing refers to creating forms of human ... -
Temperature and the ecophysiology of marine ectotherms
(Trinity College Dublin. School of Natural Sciences. Discipline of Zoology, 2023)Temperature influences the physiology, behaviour, and distribution of organisms and the field of thermal ecology has been stimulated in recent decades by the need for a greater understanding of how climate change will ... -
Essays in Energy Finance
(Trinity College Dublin. School of Business. Discipline of Business & Administrative Studies, 2023)This dissertation is composed of three main chapters related to energy finance, where the first two chapters each contain one essay and the third chapter contains two essays. In the first chapter (published in the Economic ... -
Vitamin D in the Irish Population: an analysis of prevalence and determinants
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2023)Introduction: Vitamin D has an established role in bone and muscle health, with deficiency causing rickets in children, osteomalacia in adults and contributing to the development of osteoporosis. More recently it has been ... -
Essays in Development Economics: Intrahousehold Decision Making in Developing Countries
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Economics, 2023)Providing insights into mechanisms through which households manage resources, this thesis aims to add to the empirical evidence on strategic decision-making among spouses using experimental and survey data. While the ... -
Physical function in community-dwelling older adults - a focus on health inequality and ageing in place
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis sought to explore socioeconomic determinants of physical function in community-dwelling older adults, with implications for ageing in place. While several markers of physical function are explored in this thesis, ...
