Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 1321-1340 of 7000
-
Characterisation of Depressive Symptoms in Huntington's Disease and of the Pharmacological Treatment for Depression: patterns, trends and Statistical Analysis of Enroll-HD Dataset
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: Huntington?s Disease (HD) is a rare autosomal dominant genetic disorder characterised by a triad of motor, psychiatric and cognitive symptoms. Among the psychiatric manifestations, depression is very common and ... -
Improving the Accuracy of the Winograd Convolution for Deep Neural Networks
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2022)This thesis is focused on Winograd’s fast algorithms calculating discrete convolutions. More precisely, on the most optimal in terms of the number of operations subclass of them, that is Toom-Cook algorithms. These algorithms ... -
Essays on Financial Globalisation
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Economics, 2022)This dissertation is a collection of three essays on financial globalisation. A common theme running through the essays in this dissertation is the importance of global factors shaping national macro-financial outcomes ... -
Essays in international economics
This dissertation is a collection of three independent essays in the field of international economics. A common theme running through the dissertation is that each essay touches upon a key question that central bankers ... -
Combination radiotherapy and immunotherapy: effects on the immune landscape of oesophageal adenocarcinoma and the multimodal therapeutic paradigm
The incidence of cancer of the oesophagus and the gastro-oesophageal junction (GEJ) has increased exponentially in the western world over the last half century. Oesophageal adenocarcinoma (OAC) is now the dominant subtype, ... -
Evaluation of Next-Generation Sequencing to Investigate the Epidemiology of Clostridioides difficile Infection
Introduction: Clostridioides difficile (C. difficile) is an anaerobic bacteria, which can cause gastrointestinal infection. There are approximately 2,000 cases of C. difficile infection (CDI) diagnosed in Ireland per year, ... -
The development and feasibility of the occupational therapy-led `Work and Cancer' intervention for women living with and beyond breast cancer
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2022)Background: Increased survivorship has prompted focus on optimising quality of life for those living with and beyond cancer, including reintegration into work. Despite frequently cited return-to-work barriers for women ... -
How Local Decision Making Works for Adaptations of Health Interventions During Scale-up: A Realist Review
Introduction: Scaling-up health interventions is a complex process with growing recognition of the need to make adaptations to interventions to address diverse contexts and populations encountered across multiple sites. ... -
Effect of plant diversity and drought on the agronomic performance of intensively managed grassland communities
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Statistics, 2022)Temperate agro-ecosystems are crucial for food production and financially important for the rural economy, but can have strong environmental impacts and are threatened by increased frequency of extreme weather events. Over ... -
Optimisation of Electrolytically-gated Thin Film Transistors made from Printed Nanosheet Networks
(Trinity College Dublin. School of Physics. Discipline of Physics, 2022)Networks of two-dimensional nanosheets show great potential in a wide variety of different applications, with particular focus on the area of printed electronics. One of the main issues facing such nanosheet network ... -
Naphthalimides Exhibiting Aggregation-Induced Emission for Bioimaging Applications
In this project, a 1,8-naphthalimide (Nap, compound 8) is functionalised with two triphenylamino (TPA) moieties which, by virtue of having multiple freely rotating aromatic rings, are capable of exhibiting aggregation-induced ... -
Synchronic Language Variation in the Old Irish Glosses
(Trinity College Dublin. School of Lang, Lit. & Cultural Studies. Discipline of Irish, 2022)This thesis collects, catalogues, and analyses synchronic language variation in Old Irish sources in order to investigate the possibility of Old Irish dialects. This thesis represents the first comprehensive attempt to ... -
Generation and Reactivity of Late Transition Metal Hydr(oxo) Complexes Supported by Tripodal Carboxamidate Ligand
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Metal oxo complexes (M=O) are important mediators of oxidative transformations in biological systems.1 Their high reactivity and transient nature have limited their study, with only a handful of well characterized oxo ... -
Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is a light activated therapy which involves a drug-photosensitiser (PS), light, and molecular oxygen. First, the PS is administered via a systemic or topical route and then it accumulates in the ... -
Quantum Control of Thermodynamic Processes in Semiconductors
(Trinity College Dublin. School of Physics. Discipline of Physics, 2022)In this thesis, we explore theoretically the thermodynamics of heat exchange in laser driven solid state systems. In particular, we focus on the heat exchanged between phonons and a semiconductor quantum dot exciton, driven ... -
Low Frequency Observations of the Solar Corona using LOFAR
(Trinity College Dublin. School of Physics. Discipline of Physics, 2022)The Sun is a highly dynamic, active star, dictated by the evolution of its magnetic fields, which transition from periods of maximum activity to periods of minimum activity over an 11-year cycle. During solar maximum the ... -
End-Of-Life Decision Making A Novel Entrustable Professional Activity?
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Introduction: Making tough decisions about End-Of-Life situations and palliative care in acute surgical scenarios is a non-technical skill surgeons have to master over a number of years of experience. Data suggests that ... -
Thrombin generation parameters, relationship with cerebral micro-embolic signal status, and a systematic review of the literature on platelet biomarkers in patients with symptomatic and asymptomatic carotid stenosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background:?Activation of platelets and the coagulation system are integrally involved in acute thrombus formation and distal thrombo-embolism. A better understanding of these complex thrombotic and haemostatic pathways ... -
Mother's perceptions and sense-making of their roles in speech and language therapy for children with autism in Ireland
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. Discipline of Clin Speech & Language Studies, 2022)Introduction: Parental involvement in SLT is recommended by professional bodies (e.g., RCSLT, 2009) and service providers (e.g., HSE, 2018) alike. It is necessary for the delivery of family-centred models of care and ... -
An Intercultural Theory of the Comic Spirit: Insider/Outsider Dynamics and Representation in Theatre and Performance
(Trinity College Dublin. School of Creative Arts. Discipline of Drama, 2022)This dissertation commences with an enquiry into the origins of comedy in Greek fertility rituals and nature, drawing upon theories of play, ritual, and community to explicate case studies that have been decidedly sourced ...
