Functional expression of the epithelial sodium channel δ-subunit in human respiratory epithelial cells
Citation:
Elena Schwagerus, 'Functional expression of the epithelial sodium channel δ-subunit in human respiratory epithelial cells', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012, pp 199Abstract:
Mammalian amiloride-sensitive epithelial Na+ channel (ENaC) can be composed by different combinations of four homologous subunits, α, β, γ and δ. The canonical αβγ- ENaC, abundantly expressed in Na+ absorbing epithelia, is thoroughly investigated and well known for its crucial role in Na+ homoeostasis. Via aldosterone-controlled Na+ reuptake in the kidney, ENaC regulates blood volume and pressure. In the lung, it facilitates the maintenance of alveolar lining fluid layer and efficient gas exchange. Delta-ENaC, mainly expressed in non-epithelial tissues, has recently been described in human airway epithelia. Its physiological role, however, remains largely hypothetical and is primarily based on the expression data as well as the biophysical characteristics of the heterologously expressed protein.
Author: Schwagerus, Elena
Advisor:
Ehrhardt, CarstenPublisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisCollections
Availability:
Full text availableKeywords:
Pharmacy, Ph.D., Ph.D. Trinity College DublinMetadata
Show full item recordLicences: