| dc.contributor.advisor | Mills, Kingston | |
| dc.contributor.author | Walsh, Kevin | |
| dc.date.accessioned | 2017-01-03T15:43:08Z | |
| dc.date.available | 2017-01-03T15:43:08Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Kevin Walsh, 'Regulatory T cell induction and function', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009, pp 300 | |
| dc.identifier.other | THESIS 8779 | |
| dc.description.abstract | The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production from DC and thereby induce Th1 cells. However, recent studies have suggested that TLR agonists may simultaneously induce IL-10 producing Treg (Tr1) cells. In the present study, this property was explored and exploited in order to develop methods of selectively inducing Tr1 cells, in the development of potential therapies for auto-immune diseases mediated by Th1 and IL-17 producing T (Th17) cells. | |
| dc.format | 1 volume | |
| dc.language.iso | en | |
| dc.publisher | Trinity College (Dublin, Ireland). School of Biochemistry and Immunology | |
| dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14033951 | |
| dc.subject | Biochemistry, Ph.D. | |
| dc.subject | Ph.D. Trinity College Dublin | |
| dc.title | Regulatory T cell induction and function | |
| dc.type | thesis | |
| dc.type.supercollection | thesis_dissertations | |
| dc.type.supercollection | refereed_publications | |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
| dc.rights.ecaccessrights | openAccess | |
| dc.format.extentpagination | pp 300 | |
| dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
| dc.identifier.uri | http://hdl.handle.net/2262/78647 | |
