Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 21-40 of 125
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The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture.
(2013)The biomechanical functionality of articular cartilage is derived from both its biochemical composition and the architecture of the collagen network. Failure to replicate this normal Benninghoff architecture in regenerating ... -
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
(2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents.
(2010)The design of medical devices could be very much improved if robust tools were available for computational simulation of tissue response to the presence of the implant. Such tools require algorithms to simulate the response ... -
Computer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesis
(2011)Computational modelling is becoming ever more important for obtaining regulatory approval for new medical devices. An accepted approach is to infer performance in a population from an analysis conducted in an idealized or ... -
Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions
(2018)Recent advances in the approval and commercialization of gene therapeutics have fostered the return of gene therapy to center stage. But despite new optimism, no Food and Drug Administration approved product exists for the ... -
Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad.
(2014)The objective of this study was to investigate how joint specific biomechanical loading influences the functional development and phenotypic stability of cartilage grafts engineered in vitro using stem/progenitor cells ... -
Designing Scaffolds for Corneal Regeneration
(2020)Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable ... -
Developing Microphysiological Systems of Bone Development, Physiology, and Repair
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Accurate models of human tissues and organ systems are foundational in our efforts to better understand human physiology. In the context of bone, a number of in vitro and in vivo models have been developed that facilitate ... -
Development and characterization of antacid microcapsules to buffer the acidic intervertebral disc microenvironment
(2024)During intervertebral disc (IVD) degeneration, microenvironmental challenges such as decreasing levels of glucose, oxygen, and pH play crucial roles in cell survival and matrix turnover. Antacids, such as Mg(OH)2 and CaCO3, ... -
Development and Functional Assessment of a Decellularised Injectable Biomaterial Combined with Nasal Chondrocytes for Intervertebral Disc Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Lower Back Pain (LBP) is known to be a major health issue worldwide with a significant socioeconomic impact and it is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD). IVD degeneration ... -
Development of a New Bone¿Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating
(2020)The hierarchical structure of bone plays pivotal roles in driving cell behavior and tissue regeneration and must be considered when designing materials for orthopedic applications. Herein, it is aimed to recapitulate the ... -
Development of mechanobiomimetic strategies to drive stem cell behaviour for bone regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)There are a host of cases where clinical intervention must be taken to treat diseased or damaged bone, including severe fractures, defects, tumours requiring tissue removal, and debilitating diseases such as osteoporosis. ... -
Dextran Preserves Native Corneal Structure During Decellularization.
(2016)Corneal decellularization has become an increasingly popular technique for generating scaffolds for corneal regeneration. Most decellularization procedures result in tissue swelling, thus limiting their application. Here, ... -
Digital image correlation and finite element modelling as a method to determine mechanical properties of human soft tissue in vivo.
(2009)The mechanical properties of human soft tissue are crucial for impact biomechanics, rehabilitation engineering and surgical simulation. Validation of these constitutive models using human data remains challenging and often ... -
Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint
(University of Edinburgh (datashare), 2011)Muscle contractions begin in early embryonic life, generating forces that regulate the correct formation of the skeleton. In this paper we test the hypothesis that the biophysical stimulation generated by muscle forces may ... -
The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells
(2011)Mechanical signals can play a key role in regulating the chondrogenic differentiation of Mesenchymal Stem Cells (MSCs). The objective of this study was to determine if the long-term application of cyclic hydrostatic pressure ... -
Effect of substrate topography on the regulation of human corneal stromal cells.
(2020)Optimal functionality of native corneal stroma depends on a well-ordered arrangement of extracellular matrix (ECM). To develop an in vitro corneal model, replication of the corneal in vivo microenvironment is needed. In ...