Browsing Mechanical, Manufacturing & Biomedical Eng by Title
Now showing items 291-310 of 894
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Engineering Innate Immunology in a Humanised, Functional, In Vitro Model of Healthy Myocardium
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2024)Cardiovascular disease stands as the leading cause of death globally, claiming approximately 19.05 million lives in 2020. On the contrary, the development of cardiovascular drugs is experiencing a decline, largely due to ... -
Engineering innate immunology in cardiovascular disease models and regenerative medicine
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Heart failure is the leading cause of death worldwide with atherosclerosis and myocardial infarction remaining prominent causes. It is now widely accepted that the inflammatory response holds a key role in advancing both ... -
The Engineering Investigation of the Water Flow past the Butterfly Valve
(Trinity College Dublin. School of Engineering. Mechanical & Manufacturing Engineering, 2007)This paper presents a numerical simulation of flow past the butterfly valve in static and dynamic analysis using commercial fluid dynamics software FLUENT. In static analysis, the positions of the disk were set to be 0 ( ... -
Engineering of large cartilaginous constructs through the use of microchanneled hydrogels and rotational culture
(2009)The development of functional engineered cartilaginous tissues of sufficient size that can be used clinically to treat large defects remains a major and significant challenge. This study investigated if the introduction ... -
Engineering osteochondral constructs through spatial regulation of endochondral ossification.
(2013)Chondrogenically primed bone marrow derived mesenchymal stem cells (MSCs) have been shown to become hypertrophic and undergo endochondral ossification when implanted in vivo. Modulating this endochondral phenotype may ... -
Engineering tissues with a zonal structure and composition mimicking native articular cartilage
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2015)Engineering cartilage grafts with comparable functionality to the native tissue remains a major challenge in the field of regenerative medicine. The overall goal of this thesis was to engineer a cartilage graft with ... -
Enhanced corrosion resistance and cytocompatibility of biomimetic hyaluronic acid functionalised silane coating on AZ31 Mg alloy for orthopaedic applications.
(2018)This paper reports the corrosion resistant and cytocompatible properties of the hyaluronic acid-silane coating on AZ31 Mg alloy. In this study, the osteoinductive properties of high molecular weight hyaluronic acid (HA, ... -
Environmental noise mapping using measurements in transit
(2010)Due to the ever increasing level of environmental noise that the EU population is exposed to, all countries are directed to disseminate community noise level exposures to the public in accordance with EU Directive ... -
Erosion behaviour of cold sprayed coatings made of CrMnFeCoNi high-entropy alloy or composite powders containing WC hard particles in a pure nickel matrix
(2023)The performance of two distinct coating materials under alumina particle impingement was tested in this study. CrMnFeCoNi and WC-Ni coatings were applied to 2205 duplex stainless steel substrates using cold spray method ... -
Estrogen deficiency impairs integrin ¿vß3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling.
(2019)The integrin αvβ3 has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer β3 integrin-containing cells in osteoporotic bone cells. Osteocytes cultured in vitro ... -
Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling in osteocytes.
(2021)Estrogen deficiency during post-menopausal osteoporosis leads to osteoclastogenesis and bone loss. Increased pro-osteoclastogenic signalling (RANKL/OPG) by osteocytes occurs following estrogen withdrawal (EW) and is ... -
European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate.
(2012)The aim of this study was to explore how cell-matrix interactions and extrinsic mechanical signals interact to determine stem cell fate in response to transforming growth factor-?3 (TGF-?3). Bone marrow derived mesenchymal ... -
Evaluation of bimodal microstructures in selective-laser-melted and heat-treated Ti-6Al-4V
(2023)As-built, SLM-printed Ti-6Al-4V parts suffer from non-equilibrium, brittle microstructures due to the formation of metastable α’-phase martensite as a result of the printing process. Post-processing heat treatments are ... -
Evaluation of high frequency vibrations using electronic speckle pattern interferometry
(2002)The available techniques for the study of high frequency vibration using electronic speckle pattern interferometry (ESPI) are briefly surveyed. We concentrate on two methods in particular. The first is a straightforward ... -
Evaporating hydrophilic and superhydrophobic droplets in electric fields
(2021)Evaporating water droplets on a heated substrate are investigated in this work. Specifically, the influences of electric fields are studied in the context of the heat flux distribution beneath the droplets as well as the ... -
Ex Vivo Study Using Diffusion Tensor Imaging to Identify Biomarkers of Atherosclerotic Disease in Human Cadaveric Carotid Arteries
(2022)Background: This study aims to address the potential of ex vivo diffusion tensor imaging to provide insight into the microstructural composition and morphological arrangement of aged human atherosclerotic carotid ...