Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 61-80 of 125
-
Imaging arterial fibres using diffusion tensor imaging - feasibility study & preliminary results
(2010)MR diffusion tensor imaging (DTI) was used to analyze the fibrous structure of aortic tissue. A fresh porcine aorta was imaged at 7T using a spin echo sequence with the following parameters: matrix 128 ? 128 pixel; slice ... -
The impact of decellularization methods on extracellular matrix derived hydrogels.
(2019)Tissue-derived decellularized biomaterials are ideal for tissue engineering applications as they mimic the biochemical composition of the native tissue. These materials can be used as hydrogels for cell encapsulation and ... -
In vitro co-culture and ex vivo organ culture assessment of primed and cryopreserved stromal cell microcapsules for intervertebral disc regeneration
(2019)Priming towards a discogenic phenotype and subsequent cryopreservation of microencapsulated bone marrow stromal cells (BMSCs) may offer an attractive therapeutic approach for disc repair. It potentially obviates ... -
Incorporation of collagen and hyaluronic acid to enhance the bioactivity of fibrin-based hydrogels for nucleus pulposus regeneration
(2018)Hydrogels, such as fibrin, offer a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged disc tissue as a potential treatment for low back pain. However, fibrin lacks key ... -
Influence of micropatterned substrates on keratocyte phenotype
(2020)Substrate topographic patterning is a powerful tool that can be used to manipulate cell shape and orientation. To gain a better understanding of the relationship between surface topography and keratocyte behavior, surface ... -
The influence of pH and salt concentration on the microstructure and mechanical properties of meniscus extracellular matrix-derived implants
(2024)Meniscus-related injuries are a common orthopedic challenge with an increasing incidence in the population. While the preservation of viable meniscal tissue is the preferred approach in repair strategies, complex or total ... -
Influence of polydimethylsiloxane substrate stiffness on corneal epithelial cells
(2019)Many cell types are known to modulate their behaviour in response to changes in material stiffness; however, little is known about how stiffness affects corneal epithelial cells. This study aims to investigate the response ... -
Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration
(2020)Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden. The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated ... -
Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage
(2022)Successful cartilage engineering requires the generation of biological grafts mimicking the structure, composition and mechanical behaviour of the native tissue. Here melt electrowriting (MEW) was used to produce arrays ... -
An IoT Approach for Monitoring UV Disinfection Robots
(2021)The use of ultraviolet germicidal irradiation (UVGI) technology as a means of disinfecting hospitals and other frontline settings has increased significantly in the wake of the COVID-19 pandemic. Although the science of ... -
Layer-specific stem cell differentiation in tri-layered tissue engineering biomaterials: Towards development of a single-stage cell-based approach for osteochondral defect repair
(2021)Successful repair of osteochondral defects is challenging, due in part to their complex gradient nature. Tissue engineering approaches have shown promise with the development of layered scaffolds that aim to promote cartilage ... -
Liquid immersion thermal management of lithium-ion batteries for electric vehicles: An experimental study
(2023)The thermal and electrical performance of lithium-ion batteries subjected to liquid immersion cooling conditions in a dielectric fluid has been experimentally investigated in this study. A single 26650 LiFePO4 cylindrical ... -
A Liquid-Based System for CPU Cooling Implementing a Jet Array Impingement Waterblock and a Tube Array Remote Heat Exchanger
(2012)A liquid CPU cooler has been designed and tested with the aim to achieve a cooling capacity of 200 W for a surface area of 8.24 cm2, commensurate with the integrated heat spreader dimensions of an Intel? Pentium? 4 Processor. ... -
Low oxygen tension is a more potent promoter of chondrogenic
(2010)During fracture healing and microfracture treatment of cartilage defects mesenchymal stem cells (MSCs) infiltrate the wound site, proliferate extensively and differentiate along a cartilaginous or an osteogenic lineage ... -
Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos.
(University of Edinburgh (datashare), 2011)Very little is known about the regulation of morphogenesis in synovial joints. Mechanical forces generated from muscle contractions are required for normal development of several aspects of normal skeletogenesis. Here we ...