Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 81-100 of 125
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Mechanically induced structural changes during dynamic compression of engineered cartilaginous constructs can potentially explain increases in bulk mechanical properties.
(2012)Several studies on chondrocyte seeded hydrogels in bioreactor culture report increased mechanical properties of mechanically loaded constructs compared to unloaded free swelling controls despite no significant differences ... -
Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism
(2021)Bone represents the most common site for breast cancer metastasis. Bone is a highly dynamic organ that is constantly adapting to its biophysical environment, orchestrated largely by the resident osteocyte network. Osteocytes ... -
Mechanisms of heat transfer for axisymmetric bubble impingement and rebound
(2017)Heat transfer enhancement resulting from the impingement and rebound of bubbles in confined geometries can play an important role in heat transfer applications. Limited studies exist on the impact behavior of large ellipsoidal ... -
A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies
(2010)In this study a multi-scale mechano-regulation model was developed in order to investigate the mechanobiology of trabecular fracture healing in vertebral bodies. A macro-scale finite element model of the spinal segment ... -
Multipotent vascular stem cells and the effects of cyclic tensile strain, collagen structure and stenting on medial vascular cell populations
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Atherosclerosis is one of the leading causes of mortality worldwide, and presents as a narrowing or occlusion of an artery. Interventions to re-open the arterial lumen can result in re-occlusion through intimal hyperplasia. ... -
Natural Convection heat transfer and fluid dynamics for a pair of vertically aligned isothermal horizontal cylinders.
(2011)This paper discusses the close interaction between local fluid dynamics and natural convection heat transfer from a pair of isothermally heated horizontal cylinders submerged in water. The presence of a second heated ... -
Numerical analysis of acoustic noise from an electronic cooling fan at flow disturbed by an external obstacle
(internoise2022.org, 2022-08-24)Axial cooling fans are widely used in data center dense Hard Disk Drive (HDD) storage systems. However, these fans emit high noise levels and degrade HDD performance at certain frequencies. Flow at the fan's inlet can ... -
On effect of primed cellular microcapsules and pH neutralizing biomaterials to augment regeneration of the intervertebral disc
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the most common topics of research worldwide for medical health care is low back pain (LBP). It is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD), the shock absorbent soft ... -
On the assessment of a VOF based compressive interface capturing scheme for the analysis of bubble impact on and bounce from a flat horizontal surface
(2014)The process of free rise, collision on and bounce from a solid horizontal surface for a single isolated bubble is investigated by numerical simulations based on the Volume of Fluid method (VOF). The volume fraction ... -
Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes.
(2010)Background For current tissue engineering or regenerative medicine strategies, chondrocyte (CC)- or mesenchymal stem cell (MSC)-seeded constructs are typically cultured in normoxic conditions (20% oxygen). However, within ... -
The pericellular environment regulates cytoskeletal development and the differentiation of mesenchymal stem cells and determines their response to hydrostatic pressure.
(2013)The objective of this study was to examine the interplay between matrix stiffness and hydrostatic pressure (HP) in regulating chondrogenesis of mesenchymal stem cells (MSCs) and to further elucidate the mechanotransductive ... -
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing
(2015)Clinical translation of tissue engineered therapeutics is hampered by the significant logistical and regulatory challenges associated with such products, prompting increased interest in the use of decellularized extracellular ...