Browsing Mechanical, Manufacturing & Biomedical Eng by Subject "Cartilage"
Now showing items 1-7 of 7
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Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
(2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Developing Microphysiological Systems of Bone Development, Physiology, and Repair
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Accurate models of human tissues and organ systems are foundational in our efforts to better understand human physiology. In the context of bone, a number of in vitro and in vivo models have been developed that facilitate ... -
Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering
(2019)Extracellular matrix (ECM)-derived implants hold great promise for tissue repair, but new strategies are required to produce efficiently decellularized scaffolds with the necessary porosity and mechanical properties to ... -
The identification of articular cartilage and growth plate extracellular matrix-specific proteins supportive of either osteogenesis or stable chondrogenesis of stem cells
(2020)Tissue-specific extracellular matrix (ECM) proteins can play a key role in regulating the fate of stem cells and can potentially be utilized for therapeutic applications. Realising this potential requires further ... -
Integrating non-viral gene therapy and 3D bioprinting for bone, cartilage and osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)The repair of osteochondral defects, affecting both the articular cartilage and the underlying subchondral bone, is key for the effective recovery of joint homeostasis and the prevention of further cartilage degeneration ... -
Mechanoregulatory role of TRPV4 in prenatal skeletal development
(2023)Biophysical cues are essential for guiding skeletal development, but the mechanisms underlying the mechanical regulation of cartilage and bone formation are unknown. TRPV4 is a mechanically sensitive ion channel involved ... -
Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering
(2022)Articular cartilage (AC) possesses a limited healing potential, meaning that untreated focal joint defects typically progress, leading to the development of degenerative diseases such as osteoarthritis. Several clinical ...